Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNF ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TNF |
| Full Name | Tumor Necrosis Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | immune cells and endothelial cells](/cell-types/endothelial-cells) - Activates NF-κB and MAPK pathways - [Predominantly pro-survival sign |
| Molecular Weight | 25.6 kDa |
| Amino Acids | 233 aa |
| Pathways | NF-κB, MAPK pathway |
| GeneCards | TNF |
| Human Protein Atlas | TNF |
| Associated Diseases | Ms, Tumor, Als, Depression, Inflammation, Alzheimer's disease |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TNF_ALPHA("TNF ALPHA")
TUMOR{"TUMOR"}
TNF_ALPHA -->|"expressed_in"| TUMOR
GENE_EXPRESSION["GENE EXPRESSION"]
TNF_ALPHA -->|"expressed_in"| GENE_EXPRESSION
Genes["Genes"]
TNF_ALPHA -->|"associated_with"| Genes
IMMUNE_RESPONSE(["IMMUNE RESPONSE"])
TNF_ALPHA -->|"associated_with"| IMMUNE_RESPONSE
NR3C1["NR3C1"]
NR3C1 -->|"expressed_in"| TNF_ALPHA
ESR1["ESR1"]
ESR1 -->|"expressed_in"| TNF_ALPHA
ESR2["ESR2"]
ESR2 -->|"expressed_in"| TNF_ALPHA
POMC["POMC"]
POMC -->|"expressed_in"| TNF_ALPHA
CRHR1["CRHR1"]
CRHR1 -->|"expressed_in"| TNF_ALPHA
CX3CR1["CX3CR1"]
CX3CR1 -->|"associated_with"| TNF_ALPHA
TLR2["TLR2"]
TLR2 -->|"associated_with"| TNF_ALPHA
CCL3["CCL3"]
CCL3 -->|"associated_with"| TNF_ALPHA
CCL5["CCL5"]
CCL5 -->|"associated_with"| TNF_ALPHA| Target | Relation | Type | Str |
|---|---|---|---|
| TUMOR | expressed_in | disease | 0.50 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| IMMUNE RESPONSE | associated_with | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||