concept

TNFRSF11B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF11B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

23Outgoing

14Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TNFRSF11B
Key Genes/Proteins	osteoprotegerin, OSTEOPROTEGERIN, Osteoprotegerin, HNRNPA1, VCP, RANKL
Related Diseases	Juvenile Paget's Disease, Juvenile Paget'S Disease Of Bone, Neurodegeneration, ALS, Als

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TNFRSF11B["TNFRSF11B"]
    TNFRSF11B -->|"encodes"| OSTEOPROTEGERIN["OSTEOPROTEGERIN"]
    TNFRSF11B -->|"causes"| Juvenile_Paget_s_Disease["Juvenile Paget's Disease"]
    TNFRSF11B -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TNFRSF11B -->|"activates"| ALS["ALS"]
    TNFRSF11B -->|"activates"| Als["Als"]
    TNFRSF11B -->|"activates"| HNRNPA1["HNRNPA1"]
    TNFRSF11B -->|"activates"| VCP["VCP"]
    TNFRSF11B -->|"activates"| RANKL["RANKL"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| TNFRSF11B
    GENES["GENES"] -->|"activates"| TNFRSF11B
    SQSTM1["SQSTM1"] -->|"activates"| TNFRSF11B
    TIA1["TIA1"] -->|"activates"| TNFRSF11B
    TNFRSF11A["TNFRSF11A"] -->|"activates"| TNFRSF11B
    HNRNPA2B1["HNRNPA2B1"] -->|"activates"| TNFRSF11B
    MATR3["MATR3"] -->|"activates"| TNFRSF11B
    GAIN["GAIN"] -->|"activates"| TNFRSF11B

Outgoing (23)

Target	Relation	Type	Str
osteoprotegerin	associated_with	protein	1.00
OSTEOPROTEGERIN	encodes	protein	0.95
Juvenile Paget's Disease	causes	disease	0.95
Osteoprotegerin	encodes	protein	0.95
Juvenile Paget'S Disease Of Bone	causes	disease	0.95
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
HNRNPA1	activates	gene	0.60
VCP	activates	gene	0.60
RANKL	activates	gene	0.60
RANK	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GAIN	activates	gene	0.60
AND	activates	gene	0.60
SQSTM1	activates	gene	0.60
MATR3	activates	gene	0.60
TNFRSF11A	activates	gene	0.60
JUN	activates	gene	0.60
TIA1	activates	gene	0.60
Osteoclast	activates	cell_type	0.60
App	activates	protein	0.60

Incoming (14)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
SQSTM1	activates	gene	0.60
TIA1	activates	gene	0.60
TNFRSF11A	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60
MATR3	activates	gene	0.60
GAIN	activates	gene	0.60
JUN	activates	gene	0.60
AND	activates	gene	0.60
HNRNPA1	activates	gene	0.60
VCP	activates	gene	0.60
RANKL	activates	gene	0.60
RANK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found