MATR3

Understanding Entity Pages

This page aggregates everything SciDEX knows about MATR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MATR3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, contributes to, activates. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 73 entities in the SciDEX knowledge graph.

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graph TD
    MATR3["<b>MATR3</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    MATR3 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    ALS{"ALS"}
    MATR3 -->|"associated with"| ALS
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    MATR3 -->|"associated with"| Frontotemporal_Dementia
    Dementia{"Dementia"}
    MATR3 -->|"associated with"| Dementia
    Neurodegeneration{"Neurodegeneration"}
    MATR3 -->|"associated with"| Neurodegeneration
    MATR3 -->|"activates"| ALS
    MATR3 -->|"activates"| Neurodegeneration
    TIA1["TIA1"]
    MATR3 -->|"degrades"| TIA1
    HNRNPA2B1["HNRNPA2B1"]
    MATR3 -->|"degrades"| HNRNPA2B1
    MATR3 -->|"contributes to"| TIA1
    MATR3 -->|"contributes to"| HNRNPA2B1
    VALOSIN["VALOSIN"]
    MATR3 -->|"associated with"| VALOSIN
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"degrades"| MATR3
    VALOSIN -->|"associated with"| MATR3
    NEURON["NEURON"]
    NEURON -->|"associated with"| MATR3
    GENES["GENES"]
    GENES -->|"associated with"| MATR3
    OPTN["OPTN"]
    OPTN -->|"degrades"| MATR3
    VCP["VCP"]
    VCP -->|"associated with"| MATR3
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| MATR3
    OPTINEURIN["OPTINEURIN"]
    OPTINEURIN -->|"degrades"| MATR3
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"associated with"| MATR3
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"degrades"| MATR3
    JUN["JUN"]
    JUN -->|"activates"| MATR3
    RANKL["RANKL"]
    RANKL -->|"activates"| MATR3
    style MATR3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0