protein

TIA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

258Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

TIA1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Aging, Als. Connected to 136 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TIA1
Aliases	Page for TIA1
Chromosome	2p16.3
Protein Family	TIA1/TIAR family
Function	TIA1 functions as a multifunctional RNA-binding protein with critical roles in several cellular processes.
Subcellular Localization	</strong></td><td>Cytoplasm, stress granules</td></tr>
Molecular Weight	43 kDa
Amino Acids	386 aa
Pathways	Er Stress
UniProt ID	P52912
NCBI Gene ID	4678
Ensembl ID	ENSG00000173166
OMIM	603518
GeneCards	TIA1
Human Protein Atlas	TIA1
Associated Diseases	Als, amyotrophic lateral sclerosis, dementia
Known Drugs/Compounds	rapamycin
Interactions	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, App
KG Connections	258 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TIA1 — AlphaFold P52912 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Validated Hypothesis: TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress Granule Assembly and TDP-43 Mislocalization in ALS Motor Neurons

hypothesis · 1140 words

→

TIA1 - TIA1 Cytotoxic Granule Associated RNA Binding Protein

gene · 953 words

→

Pathway Diagram

graph TD
    TIA1["TIA1"]
    TIA1 -->|"regulates"| stress_granules["stress granules"]
    TIA1 -->|"inhibits"| HSP70["HSP70"]
    TIA1 -->|"activates"| motor_neurons["motor neurons"]
    TIA1 -->|"interacts"| Cancer["Cancer"]
    TIA1 -->|"interacts"| Aging["Aging"]
    TIA1 -->|"interacts"| Ms["Ms"]
    TIA1 -->|"interacts"| Als["Als"]
    TIA1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    RRAGA["RRAGA"] -->|"interacts"| TIA1
    JUN["JUN"] -->|"interacts"| TIA1
    MAPT["MAPT"] -->|"interacts"| TIA1
    RRAGB["RRAGB"] -->|"interacts"| TIA1
    VCP["VCP"] -->|"contributes to"| TIA1
    SQSTM1["SQSTM1"] -->|"contributes to"| TIA1
    RANK["RANK"] -->|"activates"| TIA1
    RANKL["RANKL"] -->|"activates"| TIA1
    GAIN["GAIN"] -->|"activates"| TIA1

Outgoing (151)

Target	Relation	Type	Str
stress granule formation	mediates	mechanism	0.95
RNA Stress Granule	involved_in	process	0.90
Multisystem Proteinopathy	causes	disease	0.90
Welander distal myopathy	causes	disease	0.90
Neurodegeneration	activates	disease	0.75
Als	activates	disease	0.75
ALS	activates	disease	0.75
ALS	cross_disease_mechanism_in	disease	0.74
FTD	cross_disease_mechanism_in	disease	0.74
stress_granule_formation	regulates	pathway	0.70
HSP70	inhibits	protein	0.70
motor neurons	activates	cell_type	0.70
autophagy pathway	participates_in	pathway	0.70
stress granules	regulates	process	0.70
ALS	associated_with	disease	0.70
amyotrophic lateral sclerosis	associated_with	disease	0.70
Inflammation	treats	disease	0.65
Tauopathy	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Dementia	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Neuroinflammation	treats	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Ms	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Als	regulates	disease	0.65
Als	interacts_with	disease	0.65
Als	associated_with	disease	0.65
SQSTM1	degrades	gene	0.60
OPTN	degrades	gene	0.60
CNTN4	expressed_in	gene	0.60
FUS	associated_with	gene	0.60
RANK	activates	gene	0.60
GABARAP	associated_with	gene	0.60
RANKL	activates	gene	0.60
ATF4	associated_with	gene	0.60
JUN	activates	gene	0.60
neuroinflammation	associated_with	disease	0.60

Incoming (107)

Source	Relation	Type	Str
h-cross-synth-stress-granule-rbps	proposes_shared_mechanism	hypothesis	0.74
NEURODEGENERATION	activates	gene	0.70
G3BP1	associated_with	gene	0.60
JUN	interacts_with	gene	0.60
RRAGB	interacts_with	gene	0.60
JUN	activates	gene	0.60
GAIN	activates	gene	0.60
TAU	interacts_with	gene	0.60
FUS	interacts_with	protein	0.60
NEURON	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
MATR3	degrades	gene	0.60
RNA	associated_with	gene	0.60
MAPT	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
RRAGA	interacts_with	gene	0.60
TPRKB	activates	gene	0.60
GENES	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
VALOSIN	associated_with	gene	0.60
OPTN	degrades	gene	0.60
OPTINEURIN	degrades	gene	0.60
SQSTM1	degrades	gene	0.60
HNRNPA2B1	degrades	gene	0.60
C9ORF72	activates	gene	0.60
UBQLN2	activates	gene	0.60
ATXN2	associated_with	gene	0.60
CNTN4	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
BID	expressed_in	gene	0.60
TDP-43	associated_with	gene	0.60
TBC1D24	expressed_in	gene	0.60
HNRNPA1	degrades	gene	0.60
CDKN1A	activates	gene	0.60
FUS	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
ALS	activates	gene	0.60
ALS	regulates	gene	0.60
ATG	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
ATG8	associated_with	gene	0.60
LGALS8	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
CANCER	interacts_with	gene	0.60
GABARAP	associated_with	gene	0.60
ATF4	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress	0.810	als	-

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TIA1 in their description or question text

No additional research found

TIA1

Understanding Entity Pages

Summary

Wiki Pages (8)

TIA1 Protein

TIAL1 — TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1

TIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like)

TIA1L Protein

Validated Hypothesis: TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress Granule Assembly and TDP-43 Mislocalization in ALS Motor Neurons

TIA1 - TIA1 Cytotoxic Granule Associated RNA Binding Protein

Pathway Diagram

Outgoing (151)

Incoming (107)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Cross-disease neurodegeneration mechanism synthesis

What determines the specificity of RNA-protein interactions that drive distinct

RNA binding protein dysregulation across ALS FTD and AD

Experiments (0)

Related Papers (0)

Debates (4)

Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

While the study identifies G3BP1 as a central node triggering phase separation,

What are the mechanisms underlying rna binding protein dysregulation across als

Related Research

TIA1

Understanding Entity Pages

Summary

Wiki Pages (8)

TIA1 Protein

TIAL1 — TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1

TIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like)

TIA1L Protein

Validated Hypothesis: TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress Granule Assembly and TDP-43 Mislocalization in ALS Motor Neurons

TIA1 - TIA1 Cytotoxic Granule Associated RNA Binding Protein

TIA1 Protein

TIAL1 Protein (TIA1 Cytotoxic Granule-Associated RNA Binding Protein)

Pathway Diagram

Outgoing (151)

Incoming (107)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Cross-disease neurodegeneration mechanism synthesis

What determines the specificity of RNA-protein interactions that drive distinct

RNA binding protein dysregulation across ALS FTD and AD

Experiments (0)

Related Papers (0)

Debates (4)

Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

While the study identifies G3BP1 as a central node triggering phase separation,

What are the mechanisms underlying rna binding protein dysregulation across als

Related Research