Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRANSCRIPTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TRANSCRIPTION |
| Linked Hypotheses | 9 hypotheses |
Knowledge base pages for this entity
graph TD
TRANSCRIPTION["TRANSCRIPTION"]
TRANSCRIPTION -->|"mediates"| DNA_Double_Strand_Breaks["DNA Double-Strand Breaks"]
TRANSCRIPTION -->|"causes"| DNA_Lesions["DNA Lesions"]
TRANSCRIPTION -->|"involved_in"| R_Loops["R-Loops"]
PRMT["PRMT"] -->|"regulates"| TRANSCRIPTION
Biomolecular_Condensates["Biomolecular Condensates"] -->|"regulates"| TRANSCRIPTION
DNA_Damage["DNA Damage"] -->|"inhibits"| TRANSCRIPTION
UBIQUITIN["UBIQUITIN"] -->|"regulates"| TRANSCRIPTION
AHR["AHR"] -->|"involved_in"| TRANSCRIPTION
PARP1["PARP1"] -->|"regulates"| TRANSCRIPTION
P53["P53"] -->|"regulates"| TRANSCRIPTION
TP53["TP53"] -->|"regulates"| TRANSCRIPTION| Target | Relation | Type | Str |
|---|---|---|---|
| DNA Double-Strand Breaks | associated_with | process | 0.90 |
| DNA Double-Strand Breaks | mediates | process | 0.90 |
| R-Loops | associated_with | structure | 0.90 |
| DNA Lesions | causes | phenotype | 0.90 |
| Dna Double-Strand Breaks | causes | process | 0.90 |
| DNA Double-Strand Breaks | promotes | process | 0.90 |
| R-Loops | involved_in | mechanism | 0.85 |
| R-Loops | promotes | mechanism | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Transcriptional Autophagy-Lysosome Coupling | 0.665 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| MITF Acts as the Primary Transcriptional Effector Downstream | 0.444 | neurodegeneration | How does HDAC1/2 deletion specifically e |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.606
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444
neurodegeneration | 2026-04-11 | 0 hypotheses
neuroinflammation | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammati [PMID:37678798] | Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang | Cell Mol Gastroenterol Hepatol | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and inv [PMID:35176466] | Zhang L, Liang B, Xu H, Gong Y, Hu W, Ji | J Ethnopharmacol | 2022 | 1 |
| Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892] | Wang Y, An H, Liu T, Qin C, Sesaki H, Gu | Cell Rep | 2019 | 1 |
| AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310] | Song X, Zhu S, Chen P, Hou W, Wen Q, Liu | Curr Biol | 2018 | 1 |
| Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in gl [PMID:28675664] | Cid-Díaz T, Santos-Zas I, González-Sánch | J Cachexia Sarcopenia Muscle | 2017 | 1 |
| PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum [PMID:41920736] | Wang Z, Jin N, Li X, Ma X, Feng Y, Yin K | Cell reports | 2026 | 0 |
| Mammalian lipophagy: process and function. [PMID:41681129] | Zhao R, Dai E, Kang R, Liu J, Klionsky D | Autophagy | 2026 | 0 |
| TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiqu [PMID:41921828] | ["Xin Y", "Sun Y", "Pan E", "Li M", "Che | Free radical biology & medicin | 2026 | 0 |
| Combining network pharmacology and multi-omics reveals the role of Shengdihuang- [PMID:41655545] | Cao X, Shang Y, Qu M, Kang Q, Xu Y et al | Phytomedicine | 2026 | 0 |
| A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling an [PMID:41718717] | Golec DP, Gazzinelli-Guimaraes PH, Chaus | J Exp Med | 2026 | 0 |
| Comparative transcriptomics of adherent and suspension chicken fibroblast cell l [PMID:41763754] | Contreras EJ, Nagarajan A, Bromberg BH, | Food Res Int | 2026 | 0 |
| FOXO1 transcription factor modulates airway epithelial responses to viral infect [PMID:41931532] | Daniel NM, Mann-Nüttel R, Shrestha Palik | PLoS One | 2026 | 0 |
| Clinical and immunological significance of FOXO1 as a biomarker of improved resp [PMID:41935603] | Du L, Wang J, Wang Y, Wang H, Xu X et al | Eur J Pharmacol | 2026 | 0 |
| Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cell [PMID:41945556] | Yan Z, Chi W, Yan Z, Wang H | PLoS One | 2026 | 0 |
| Ponatinib inhibits LCK and PI3K signaling and promotes CD8(+) T stem cell memory [PMID:41946709] | Okuhiro Y, Ito S, Watanabe K, Yan Y, Kum | Nat Commun | 2026 | 0 |
| Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerb [PMID:41950099] | Oyabu M, Sakaue M, Kubo A, Yoshioka K, K | Proc Natl Acad Sci U S A | 2026 | 0 |
| The deubiquitinase activity of CYLD is required for B cell differentiation. [PMID:41951576] | Pseftogas A, Bordini J, Gavriilidis G, F | Cell Death Dis | 2026 | 0 |
| Effects of Vitamin A Restriction on Carcass Characteristics, Antioxidant Capacit [PMID:41856090] | Zhang X, Zhang C, Song J, Bai J, Hao B, | Animal bioscience | 2026 | 0 |
| Transcriptomic identification of CREB1 and FOXO1 activation in neuregulin-1-medi [PMID:41907189] | Bennett KR, Surles-Zeigler MC, Augello C | Frontiers in molecular neurosc | 2026 | 0 |