Mechanosensitive Epigenetic Transcription (MET)
🧪 Overview
Mechanical stress triggers mechanosensitive transcription factors that recruit epigenetic modifiers, explaining physical stimuli-induced epigenetic changes
Debate provenance: derived from debate `sess_SDA-2026-04-10-SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b` on question: Do different priming stimuli require distinct therapeutic approaches or share common epigenetic pathways?. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms Epigenetic, MET, Mechanosensitive, Transcription, YAP1, epigenetic. Novelty signal: skeptic-discussed-with-qualified-concession.
🧬 Mechanism
Auto-built from this analysis's top knowledge-graph edges.
graph TD
metabolic_stress["metabolic stress"] -->|regulates| Chromatin_Accessibility["Chromatin Accessibility"]
SIRT1["SIRT1"] -->|regulates| NAD__Metabolism["NAD+ Metabolism"]
ampk["ampk"] -->|regulates| ENERGY_HOMEOSTASIS["ENERGY_HOMEOSTASIS"]
KAT2A["KAT2A"] -->|regulates| histone_acetylation["histone acetylation"]
Nad_["Nad+"] -->|regulates| SIRT1_activity["SIRT1 activity"]
acetyl_CoA["acetyl-CoA"] -->|regulates| histone_acetylation_1["histone acetylation"]
SIRT1_2["SIRT1"] -->|regulates| Chromatin_Accessibility_3["Chromatin Accessibility"]
metabolic_stress_4["metabolic stress"] -->|regulates| epigenetic_enzymes["epigenetic enzymes"]
KAT2A_5["KAT2A"] -->|associated with| histone_acetylation_6["histone acetylation"]
SIRT1_7["SIRT1"] -->|regulates| NAD__metabolism["NAD+ metabolism"]
AMPK["AMPK"] -->|regulates| energy_homeostasis["energy homeostasis"]
KAT2A_8["KAT2A"] -->|catalyzes| histone_acetylation_9["histone acetylation"]
style metabolic_stress fill:#4fc3f7,stroke:#333,color:#000
style Chromatin_Accessibility fill:#4fc3f7,stroke:#333,color:#000
style SIRT1 fill:#ce93d8,stroke:#333,color:#000
style NAD__Metabolism fill:#81c784,stroke:#333,color:#000
style ampk fill:#4fc3f7,stroke:#333,color:#000
style ENERGY_HOMEOSTASIS fill:#81c784,stroke:#333,color:#000
style KAT2A fill:#ce93d8,stroke:#333,color:#000
style histone_acetylation fill:#4fc3f7,stroke:#333,color:#000
style Nad_ fill:#4fc3f7,stroke:#333,color:#000
style SIRT1_activity fill:#4fc3f7,stroke:#333,color:#000
style acetyl_CoA fill:#4fc3f7,stroke:#333,color:#000
style histone_acetylation_1 fill:#4fc3f7,stroke:#333,color:#000
style SIRT1_2 fill:#ce93d8,stroke:#333,color:#000
style Chromatin_Accessibility_3 fill:#4fc3f7,stroke:#333,color:#000
style metabolic_stress_4 fill:#4fc3f7,stroke:#333,color:#000
style epigenetic_enzymes fill:#4fc3f7,stroke:#333,color:#000
style KAT2A_5 fill:#ce93d8,stroke:#333,color:#000
style histone_acetylation_6 fill:#4fc3f7,stroke:#333,color:#000
style SIRT1_7 fill:#ce93d8,stroke:#333,color:#000
style NAD__metabolism fill:#81c784,stroke:#333,color:#000
style AMPK fill:#4fc3f7,stroke:#333,color:#000
style energy_homeostasis fill:#81c784,stroke:#333,color:#000
style KAT2A_8 fill:#ce93d8,stroke:#333,color:#000
style histone_acetylation_9 fill:#4fc3f7,stroke:#333,color:#000⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — YAP1
No curated PDB or AlphaFold mapping for YAP1 yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for YAP1.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_round_mining
| source | v1_phase_c_backfill |
| origin_type | debate_round_mining |
| _schema_version | 1 |