TRIM28

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM28: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TRIM28 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, implicated in. Associated with Cancer, Carcinoma, Tumor. Connected to 16 entities in the SciDEX knowledge graph.

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graph TD
    TRIM28["<b>TRIM28</b>"]
    Tumor{"Tumor"}
    TRIM28 -->|"activates"| Tumor
    Carcinoma{"Carcinoma"}
    TRIM28 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    TRIM28 -->|"activates"| Cancer
    SLC7A11["SLC7A11"]
    TRIM28 -->|"activates"| SLC7A11
    STAT6["STAT6"]
    TRIM28 -->|"activates"| STAT6
    HDAC5["HDAC5"]
    TRIM28 -->|"activates"| HDAC5
    Ferroptosis(["Ferroptosis"])
    TRIM28 -->|"activates"| Ferroptosis
    FERROPTOSIS["FERROPTOSIS"]
    TRIM28 -->|"activates"| FERROPTOSIS
    CANCER["CANCER"]
    TRIM28 -->|"activates"| CANCER
    TRIM28 -->|"inhibits"| HDAC5
    neurodegeneration["neurodegeneration"]
    TRIM28 -->|"implicated in"| neurodegeneration
    CANCER -->|"activates"| TRIM28
    FERROPTOSIS -->|"activates"| TRIM28
    SLC7A11 -->|"activates"| TRIM28
    STAT6 -->|"activates"| TRIM28
    AND["AND"]
    AND -->|"activates"| TRIM28
    HDAC5 -->|"activates"| TRIM28
    style TRIM28 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0