protein

TRIM28

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM28: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

1Hypotheses

1Analyses

17Outgoing

12Incoming

0Experiments

1Debates

Summary

TRIM28 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, implicated in. Associated with Cancer, Carcinoma, Tumor. Connected to 16 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TRIM28
Full Name	Transcriptional Intermediary Factor 1 Beta (TIF1β)
Aliases	Transcriptional Intermediary Factor 1 Beta
Protein Family	TRIM family, transcriptional co-repressors
Function	Upon KRAB-ZFP binding to DNA, TRIM28 is recruited through interaction with the KRAB domain.
Subcellular Localization	Nucleus (predominantly), also in cytoplasm
Molecular Weight	110 kDa (835 amino acids)
Amino Acids	835 aa
Pathways	Ferroptosis
UniProt ID	Q13263
GeneCards	TRIM28
Human Protein Atlas	TRIM28
Associated Diseases	neurodegeneration
Interactions	AND, CANCER, DNA, FERROPTOSIS, HDAC5, RAD18
SciDEX Hypotheses	Stress-Activated Retrotransposon Epigenetic Regula
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TRIM28 — AlphaFold Q13263 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRIM28 (KAP1) Protein

protein · 1263 words

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Pathway Diagram

graph TD
    TRIM28["TRIM28"]
    Tumor{"Tumor"}
    TRIM28 -->|"activates"| Tumor
    Carcinoma{"Carcinoma"}
    TRIM28 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    TRIM28 -->|"activates"| Cancer
    SLC7A11["SLC7A11"]
    TRIM28 -->|"activates"| SLC7A11
    STAT6["STAT6"]
    TRIM28 -->|"activates"| STAT6
    HDAC5["HDAC5"]
    TRIM28 -->|"activates"| HDAC5
    Ferroptosis(["Ferroptosis"])
    TRIM28 -->|"activates"| Ferroptosis
    FERROPTOSIS["FERROPTOSIS"]
    TRIM28 -->|"activates"| FERROPTOSIS
    CANCER["CANCER"]
    TRIM28 -->|"activates"| CANCER
    TRIM28 -->|"inhibits"| HDAC5
    neurodegeneration["neurodegeneration"]
    TRIM28 -->|"implicated in"| neurodegeneration
    CANCER -->|"activates"| TRIM28
    FERROPTOSIS -->|"activates"| TRIM28
    SLC7A11 -->|"activates"| TRIM28
    STAT6 -->|"activates"| TRIM28
    AND["AND"]
    AND -->|"activates"| TRIM28
    HDAC5 -->|"activates"| TRIM28
    style TRIM28 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
retrotransposon suppression	maintains	process	0.70
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
HDAC5	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
CANCER	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
SLC7A11	activates	gene	0.60
STAT6	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
AND	activates	gene	0.60
HDAC5	inhibits	protein	0.56
retrotransposon suppression	regulates	process	0.50
WAS	activates	protein	0.50

Incoming (12)

Source	Relation	Type	Str
SLC7A11	activates	gene	0.60
STAT6	activates	gene	0.60
HDAC5	activates	gene	0.60
HDAC5	phosphorylates	entity	0.60
RAD18	interacts_with	gene	0.60
CANCER	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
SIK1	activates	gene	0.60
DNA	interacts_with	gene	0.60
STING	co_discussed	gene	0.50
TRIM2	co_discussed	gene	0.50
SLC7A1	co_discussed	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Stress-Activated Retrotransposon Epigenetic Regulation (SARE	0.000	-	Do different priming stimuli require dis

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do different priming stimuli require distinct therapeutic approaches or share co

immunology | 2026-04-08 | 8 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do different priming stimuli require distinct therapeutic approaches or share co

closed · Rounds: 4 · Score: 0.93 · 2026-04-10

Related Research

Hypotheses and analyses mentioning TRIM28 in their description or question text

No additional research found