Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRPC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TRPC3 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily C Member 3 |
| Chromosome | 4q27 |
| Protein Type | Receptor |
| Function | TRPC3 is a non-selective cation channel involved in synaptic plasticity and motor coordination. |
| Primary Expression | the nervous system and participate in sensory perception, neuroprotection, and disease processes |
| UniProt ID | [Q9UQC2](https://www.uniprot.org/uniprotkb/Q9UQC2/entry) |
| GeneCards | TRPC3 |
| Human Protein Atlas | TRPC3 |
| Associated Diseases | Ataxia, synaptic plasticity |
| Interactions | PI3K, MIRO1, TRKB, BDNF, TRPC6, CAV1 |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["TRPC3"]
N1["PI3K"]
N0 -->|"activates"| N1
N2["MIRO1"]
N0 -->|"activates"| N2
N3["TRKB"]
N0 -->|"activates"| N3
N4["Neuron"]
N0 -->|"activates"| N4
N5["BDNF"]
N0 -->|"activates"| N5
N6["TRPC6"]
N0 -->|"activates"| N6
N7["MITOCHONDRIA"]
N0 -->|"activates"| N7
N8["AND"]
N0 -->|"activates"| N8
N9["Bdnf"]
N0 -->|"activates"| N9
N10["App"]
N0 -->|"activates"| N10
N11["CAV1"]
N0 -->|"activates"| N11
N12["CAV3"]
N0 -->|"activates"| N12
N13["Rb"]
N0 -->|"interacts with"| N13
N14["Ras"]
N0 -->|"activates"| N14
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 gene
class N3 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 protein
class N10 protein
class N11 gene
class N12 gene
class N13 protein
class N14 protein| Target | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | gene | 0.60 |
| MIRO1 | activates | gene | 0.60 |
| TRKB | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| TRPC6 | activates | gene | 0.60 |
| CAV1 | activates | gene | 0.60 |
| CAV3 | activates | gene | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| Bdnf | activates | protein | 0.60 |
| App | activates | protein | 0.60 |
| Ras | activates | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | activates | gene | 0.60 |
| TRPC6 | activates | gene | 0.60 |
| MIRO1 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||