gene

TRPC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections
0Hypotheses
0Analyses
15Outgoing
5Incoming

Summary

TRPC3 Gene

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🧬 Gene Info
Gene SymbolTRPC3
Full NameTransient Receptor Potential Cation Channel Subfamily C Member 3
Chromosome4q27
Protein TypeReceptor
FunctionTRPC3 is a non-selective cation channel involved in synaptic plasticity and motor coordination.
Primary Expressionthe nervous system and participate in sensory perception, neuroprotection, and disease processes
UniProt ID[Q9UQC2](https://www.uniprot.org/uniprotkb/Q9UQC2/entry)
GeneCardsTRPC3
Human Protein AtlasTRPC3
Associated DiseasesAtaxia, synaptic plasticity
InteractionsPI3K, MIRO1, TRKB, BDNF, TRPC6, CAV1
KG Connections20 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

TRPC3 Gene

gene · 618 words

Ion Channel Dysfunction in Huntington's Disease

mechanism · 3782 words

Calcium Signaling Pathway in Neurodegeneration

mechanism · 3338 words

GRM1 Gene

entity · 2182 words

TRPC7

gene · 1661 words

Accessory Olivary Neurons

cell · 1271 words

Pathway Diagram

flowchart TD
    N0["TRPC3"]
    N1["PI3K"]
    N0 -->|"activates"| N1
    N2["MIRO1"]
    N0 -->|"activates"| N2
    N3["TRKB"]
    N0 -->|"activates"| N3
    N4["Neuron"]
    N0 -->|"activates"| N4
    N5["BDNF"]
    N0 -->|"activates"| N5
    N6["TRPC6"]
    N0 -->|"activates"| N6
    N7["MITOCHONDRIA"]
    N0 -->|"activates"| N7
    N8["AND"]
    N0 -->|"activates"| N8
    N9["Bdnf"]
    N0 -->|"activates"| N9
    N10["App"]
    N0 -->|"activates"| N10
    N11["CAV1"]
    N0 -->|"activates"| N11
    N12["CAV3"]
    N0 -->|"activates"| N12
    N13["Rb"]
    N0 -->|"interacts with"| N13
    N14["Ras"]
    N0 -->|"activates"| N14

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 protein
    class N10 protein
    class N11 gene
    class N12 gene
    class N13 protein
    class N14 protein

Outgoing (15)

TargetRelationTypeStr
PI3Kactivatesgene0.60
MIRO1activatesgene0.60
TRKBactivatesgene0.60
BDNFactivatesgene0.60
TRPC6activatesgene0.60

Incoming (5)

SourceRelationTypeStr
BDNFactivatesgene0.60
TRPC6activatesgene0.60
MIRO1activatesgene0.60
PI3Kactivatesgene0.60
MITOCHONDRIAactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found