gene 618 words KG: TRPC3 2026-03-24
kind:genesection:genesstate:published
Contents

TRPC3 Gene

🧬 Gene Info
Gene SymbolTRPC3
Full NameTransient Receptor Potential Cation Channel Subfamily C Member 3
Chromosome4q27
Protein TypeReceptor
FunctionTRPC3 is a non-selective cation channel involved in synaptic plasticity and motor coordination.
Primary Expressionthe nervous system and participate in sensory perception, neuroprotection, and disease processes
UniProt ID[Q9UQC2](https://www.uniprot.org/uniprotkb/Q9UQC2/entry)
GeneCardsTRPC3
Human Protein AtlasTRPC3
Associated DiseasesAtaxia, synaptic plasticity
InteractionsPI3K, MIRO1, TRKB, BDNF, TRPC6, CAV1
KG Connections20 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (11)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
TRPC6 Gene
gene · KG edge: activates
TRKB Gene
gene · KG edge: activates
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: activates

Knowledge Graph (12 edges)

TRPC3 activates PI3K
TRPC3 activates MIRO1
TRPC3 activates TRKB
TRPC3 activates BDNF
TRPC3 activates TRPC6
TRPC3 activates CAV1
TRPC3 activates CAV3
TRPC3 interacts_with Rb
TRPC3 activates Neuron
TRPC3 activates MITOCHONDRIA