protein

TSC2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TSC2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	TSC2PROTEIN
Function	is a tumor suppressor protein that forms a heterodimeric complex with TSC1 (hamartin) to regulate mTORC1 signaling.
Subcellular Localization	\| \| Lysosomal recruitment \| Complex localizes to lysosomes for Rheb regulation \|
Molecular Weight	198 kDa
GeneCards	TSC2PROTEIN
Human Protein Atlas	TSC2PROTEIN
N-terminal domain	TSC1-binding region
GAP domain (Rhodanese homology domain)	GTPase-activating protein function
Transactivation domain	C-terminal region for transcriptional regulation
Multiple phosphorylation sites	For regulation by kinases including AKT, AMPK, and GSK3β
Growth factor signaling	PI3K/AKT phosphorylates and inhibits TSC2
Energy sensing	AMPK activates TSC2 during energy stress
Nutrient sensing	Amino acids activate mTORC1 independently of TSC
Autophagy impairment	TSC2/mTOR affects alpha-synuclein clearance
Lysosomal function	TSC2 regulates lysosomal biogenesis
Associated Diseases	ALS, Diabetes, epilepsy, Ms, neurodegeneration, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	ACETYL-COA, ACTB, Akt, AKT, AKT1, AKT3
KG Connections	346 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Tuberin Protein

protein · 554 words

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Pathway Diagram

graph TD
    TSC2PROTEIN["TSC2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TSC2PROTEIN -->|"implicated_in"| neurodegeneration
    style TSC2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning TSC2PROTEIN in their description or question text

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