gene

aldh1a2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aldh1a2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

26Outgoing

10Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ALDH1A2
Full Name	Aldehyde Dehydrogenase 1 Family Member A2
Chromosome	15q21.2
Protein Type	Enzyme
Function	is a crucial enzyme in the retinoic acid biosynthesis pathway.
Primary Expression	multiple tissues with distinct patterns:
Molecular Weight	56 kDa
Amino Acids	493 aa
Exons	14
UniProt ID	O00469
NCBI Gene ID	8854
Ensembl ID	ENSG00000128918
OMIM	603687
GeneCards	ALDH1A2
Human Protein Atlas	ALDH1A2
Associated Diseases	Neurodegeneration, neurodegeneration
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: aldh1a2 — AlphaFold O00469 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ALDH1A2 (Aldehyde Dehydrogenase 1 Family Member A2)

gene · 1681 words

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Pathway Diagram

graph TD
    ALDH1A2["ALDH1A2"]
    ALDH1A2 -->|"contributes to"| Spinal_Muscular_Atrophy["Spinal Muscular Atrophy"]
    ALDH1A2 -->|"activates"| Neuron["Neuron"]
    ALDH1A2 -->|"expressed in"| SMN["SMN"]
    ALDH1A2 -->|"expressed in"| SMN1["SMN1"]
    ALDH1A2 -->|"regulates"| MOTOR_NEURON["MOTOR NEURON"]
    ALDH1A2 -->|"regulates"| Genes["Genes"]
    NEURON["NEURON"] -->|"activates"| ALDH1A2
    SMN1 -->|"expressed in"| ALDH1A2
    GENES["GENES"] -->|"regulates"| ALDH1A2
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"regulates"| ALDH1A2
    AND["AND"] -->|"regulates"| ALDH1A2
    SMN -->|"expressed in"| ALDH1A2

Outgoing (26)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ALDH1A2	data_in	dataset_row	0.00
Spinal Muscular Atrophy	contributes_to	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuron	activates	cell_type	0.60
SMN1	expressed_in	gene	0.60
IRS1	activates	gene	0.60
IDH1	activates	gene	0.60
ITPKA	activates	gene	0.60
LPL	activates	gene	0.60
P2RX1	activates	gene	0.60
SPTLC2	activates	gene	0.60
SYNE2	activates	gene	0.60
SMN	expressed_in	gene	0.60
Neuron	expressed_in	cell_type	0.55
MOTOR NEURONS	regulates	concept	0.50
NEURONS	regulates	concept	0.50
Neuron	associated_with	cell_type	0.50
MOTOR NEURON	associated_with	concept	0.50
Neuron	protects_against	cell_type	0.50
MOTOR NEURONS	protects_against	concept	0.50
NEURONS	protects_against	concept	0.50
MOTOR NEURON	protects_against	concept	0.50
Neuron	activates	cell_type	0.50
MOTOR NEURON	activates	concept	0.50
Neuron	regulates	cell_type	0.50
MOTOR NEURON	regulates	concept	0.50

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ALDH1A2	data_in	dataset_row	0.00
SMN1	expressed_in	gene	0.60
SMN	expressed_in	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GENES	regulates	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
AND	regulates	gene	0.60
NEURON	activates	gene	0.60
ADRA2A	activates	gene	0.60
Neurodegeneration	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity