protein

SMN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

44Incoming

Summary

Page for SMN Protein

View on Wiki →

🔬 Protein Info

Gene Symbol	SMN
Chromosome	5q13.2.
Function	SMN is essential for cellular viability, and complete absence is embryonically lethal.
Primary Expression	Spinal Cord, Ca1, Cerebellum
Molecular Weight	38 kDa
Amino Acids	294 aa
Exons	2
Pathways	Tdp-43, Apoptosis, Er Stress, Cell Cycle, CRISPR-Cas
GeneCards	SMN
Human Protein Atlas	SMN
Gene [^6] [SMN1](/entities/smn1) [^7] [^8] [^9] UniProt [^10] Q16637 [^11] [^12] [@external] PDB [^14] 4A4G (Tudor domain), 4GLI (YG-dimer) [^15] [^16] [^17] Mol. Weight [@ref] ~38 kDa (294 amino acids) [@smn] [@refa] [@omim] Localization [@ncbi] Nucleus (gems/Cajal bodies), cytoplasm Family	Tudor domain protein family
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Spinal Muscular Atrophy
Interactions	STMN2, TDP-43, CHMP7, Rb, ALS, NEURON
KG Connections	121 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SMN["<b>SMN</b>"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMN -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    Aging["Aging"]
    SMN -->|"interacts with"| Aging
    ALS["ALS"]
    SMN -->|"associated with"| ALS
    Neurodegeneration["Neurodegeneration"]
    SMN -->|"expressed in"| Neurodegeneration
    Dementia["Dementia"]
    SMN -->|"associated with"| Dementia
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMN -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    SMN -->|"associated with"| Frontotemporal_Dementia
    ALS["ALS"]
    SMN -->|"activates"| ALS
    Tdp_43["Tdp-43"]
    SMN -->|"interacts with"| Tdp_43
    SMN2["SMN2"]
    SMN -->|"associated with"| SMN2
    GENES["GENES"]
    SMN -->|"expressed in"| GENES
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    SMN -->|"associated with"| AMYOTROPHIC_LATERAL_SCLEROSIS
    TIA1["TIA1"]
    SMN -->|"associated with"| TIA1
    CNTN4["CNTN4"]
    SMN -->|"expressed in"| CNTN4
    Tdp_43["Tdp-43"]
    SMN -->|"associated with"| Tdp_43
    Apoptosis["Apoptosis"]
    SMN -->|"expressed in"| Apoptosis
    Er_Stress["Er Stress"]
    SMN -->|"associated with"| Er_Stress
    Cell_Cycle["Cell Cycle"]
    SMN -->|"expressed in"| Cell_Cycle
    FUS["FUS"]
    FUS -->|"co expressed with"| SMN
    STMN2["STMN2"]
    STMN2 -->|"interacts with"| SMN
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"interacts with"| SMN
    TDP_43["TDP-43"]
    TDP_43 -->|"interacts with"| SMN
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"interacts with"| SMN
    SMD1["SMD1"]
    SMD1 -->|"interacts with"| SMN
    RNA["RNA"]
    RNA -->|"interacts with"| SMN
    AND["AND"]
    AND -->|"activates"| SMN
    NEURON["NEURON"]
    NEURON -->|"interacts with"| SMN
    CHMP7["CHMP7"]
    CHMP7 -->|"interacts with"| SMN
    AND["AND"]
    AND -->|"interacts with"| SMN
    SMN1["SMN1"]
    SMN1 -->|"causes"| SMN

Outgoing (77)

Target	Relation	Type	Str
CHMP7	regulates	protein	0.95
neurons	expressed_in	cell_type	0.80
Spinal Muscular Atrophy	interacts_with	disease	0.65
Spinal Muscular Atrophy	causes	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
SMN2	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
CNTN4	expressed_in	gene	0.60
STMN2	interacts_with	gene	0.60
TDP-43	interacts_with	gene	0.60
CHMP7	interacts_with	gene	0.60
SMN1	causes	gene	0.60
ALDH1A2	expressed_in	gene	0.60
CCNF	encodes	gene	0.60
TBC1D24	encodes	gene	0.60
BID	encodes	gene	0.60
Rb	interacts_with	protein	0.60
PLIN4	expressed_in	gene	0.60
HNRNPA1	associated_with	gene	0.60
CDKN1A	expressed_in	gene	0.60
ATXN2	associated_with	gene	0.60
FUS	associated_with	gene	0.60
ER stress	associated_with	process	0.60
frontotemporal	associated_with	disease	0.60
neurodegeneration	expressed_in	disease	0.60
ALS	activates	gene	0.60
Tdp-43	interacts_with	pathway	0.60
GENES	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Er Stress	associated_with	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
NEURON	interacts_with	gene	0.60
SMD1	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
Stem Cell	activates	cell_type	0.60
Neuron	interacts_with	cell_type	0.60
Actin	interacts_with	protein	0.60
NEURON	expressed_in	gene	0.60
NEURON	causes	gene	0.60

Incoming (44)

Source	Relation	Type	Str
FUS	co_expressed_with	protein	0.60
STMN2	interacts_with	gene	0.60
TDP-43	interacts_with	gene	0.60
CHMP7	interacts_with	gene	0.60
SMN1	causes	gene	0.60
ALDH1A2	expressed_in	gene	0.60
TBC1D24	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
FUS	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
BID	expressed_in	gene	0.60
HNRNPA1	associated_with	gene	0.60
CCNF	expressed_in	gene	0.60
TDP-43	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
CDKN1A	expressed_in	gene	0.60
PLIN4	encodes	gene	0.60
CNTN4	encodes	gene	0.60
CHMP7	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
SMD1	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AND	activates	gene	0.60
NEURON	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
NEURON	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AND	causes	gene	0.60
NEURON	causes	gene	0.60
NEURON	associated_with	gene	0.60
ALS	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
TPRKB	expressed_in	gene	0.60
AND	associated_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ALS	activates	gene	0.60
ALS	interacts_with	gene	0.60
HNRNPA2B1	co_expressed_with	gene	0.50
MAPT	co_expressed_with	gene	0.50
CHMP7	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SMN

Understanding Entity Pages

Summary

Wiki Pages (21)

Survival Motor Neuron (SMN)

TRA2B Protein - Transformer-2 Beta

Splice-Modulating Therapies for Neurodegeneration

Gemin-8 Protein

CNTFR Gene

RNASEK — Ribonuclease Kappa

Gemin-6 Protein

TAR DNA-Binding Protein 43 (TDP-43)

Spliceosome and Neurodegeneration

HNRNPR Gene

Antisense Oligonucleotide Therapy for Neurodegeneration

RNA Splicing Defects in Neurodegeneration

spinal-motoneurons-sma

HNRNPG — Heterogeneous Nuclear Ribonucleoprotein G

GEMIN8 Gene

fbxo38

risdiplam

HNRNPH2 Gene

PRPF3 — Pre-mRNA Processing Factor 3