gene

SYNE2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections

0Hypotheses

0Analyses

39Outgoing

48Incoming

Summary

SYNE2 encodes nesprin-2, a nuclear envelope protein involved in the LINC complex, implicated in Emery-Dreifuss muscular dystrophy and neurodegeneration

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🧬 Gene Info

Gene Symbol	SYNE2
Full Name	Spectrin Repeat Containing Nuclear Envelope Protein 2
Chromosome	14q23.1
Protein Type	Nuclear envelope protein (Nesprin family)
Function	is a multi-isofor protein generated by alternative splicing, with the giant isoform (nesprin-2 giant, ~800 kDa) being the most studied in the context of nuclear envelope integrity and mechanotransd...
Primary Expression	Heart, Skeletal muscle, Brain, Endothelium
Subcellular Localization	the nuclear envelope that forms the core component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. The
Molecular Weight	800 kDa
Gene Type	Protein coding
UniProt ID	Q8WXR4
NCBI Gene ID	23224
Ensembl ID	ENSG00000008952
OMIM	608687
GeneCards	SYNE2
Human Protein Atlas	SYNE2
Associated Diseases	ALS, Alzheimer
Interactions	SMARCB1, TMEM59, PRDX3, SSBP1, CALB1, RNF14
KG Connections	87 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SYNE2 — AlphaFold Q8WXR4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYNE2["SYNE2"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    SMARCB1["SMARCB1"]
    ULK2["ULK2"]
    TMEM59["TMEM59"]
    SFPQ["SFPQ"]
    CCT4["CCT4"]
    CALB1["CALB1"]
    SORL1["SORL1"]
    IGF2R["IGF2R"]
    COPA["COPA"]
    STXBP3["STXBP3"]
    RNF14["RNF14"]
    IDS["IDS"]
    SYNCRIP["SYNCRIP"]
    SSBP1["SSBP1"]
    PRDX3["PRDX3"]
    APP["APP"]
    ALZHEIMER["ALZHEIMER"]
    APOE["APOE"]
    SYNE2 -.-|"associated"| Alzheimer
    SYNE2 -.-|"associated"| Als
    SYNE2 -.-|"associated"| SMARCB1
    SYNE2 -.-|"associated"| ULK2
    SYNE2 -.-|"associated"| TMEM59
    SYNE2 -.-|"associated"| SFPQ
    SYNE2 -.-|"associated"| CCT4
    SYNE2 -.-|"associated"| CALB1
    SYNE2 -.-|"associated"| SORL1
    SYNE2 -.-|"associated"| IGF2R
    SYNE2 -.-|"associated"| COPA
    SYNE2 -.-|"associated"| STXBP3
    SYNE2 -.-|"associated"| RNF14
    IDS -.-|"associated"| SYNE2
    SYNCRIP -.-|"associated"| SYNE2
    SSBP1 -.-|"associated"| SYNE2
    PRDX3 -.-|"associated"| SYNE2
    APP -.-|"associated"| SYNE2
    ALZHEIMER -.-|"associated"| SYNE2
    APOE -.-|"associated"| SYNE2
    style SYNE2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (39)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
TMEM59	binds_to	gene	0.60
COPA	associated_with	gene	0.60
Igf	associated_with	protein	0.60
Alzheimer's disease	interacts_with	disease	0.60
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50
PRDX3	interacts_with	gene	0.50
SSBP1	interacts_with	gene	0.50
CALB1	interacts_with	gene	0.50
RNF14	interacts_with	gene	0.50
CCT4	interacts_with	gene	0.50
ULK2	interacts_with	gene	0.50
STXBP3	interacts_with	gene	0.50
SORL1	interacts_with	gene	0.50
SFPQ	interacts_with	protein	0.50
IGF2R	interacts_with	protein	0.50
SYNCRIP	interacts_with	concept	0.50
COPA	interacts_with	protein	0.50
ALZHEIMER	interacts_with	gene	0.50
ALZHEIMER'S	interacts_with	concept	0.50

Incoming (48)

Source	Relation	Type	Str
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
APP	interacts_with	gene	0.60
CALB1	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
PRDX3	interacts_with	gene	0.60
RNF14	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SMARCB1	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
STXBP3	interacts_with	gene	0.60
SYNCRIP	interacts_with	gene	0.60
APOE	binds_to	gene	0.60
IGF2R	binds_to	gene	0.60
SYNCRIP	binds_to	gene	0.60
PRDX3	binds_to	gene	0.60
SMARCB1	binds_to	gene	0.60
ADRA2A	activates	gene	0.60
ALDH1A2	activates	gene	0.60
IDH1	activates	gene	0.60
ITPKA	activates	gene	0.60
LPL	activates	gene	0.60
P2RX1	activates	gene	0.60
SPTLC2	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
COPA	interacts_with	gene	0.60
IRS1	activates	gene	0.60
APOE	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SYNE2

Understanding Entity Pages

Summary

Wiki Pages (7)

SYNE2 Gene

CALB1 (Calbindin 1)

SPTLC2 Gene

SYNE1 Gene - Spectrin Repeat Containing Nuclear Envelope Protein 1

PRDX3 — Peroxiredoxin 3