gene

LPL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

258Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

LPL is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Alzheimer. Connected to 109 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolLPL
Full NameLipoprotein Lipase
Protein TypeEnzyme
FunctionLipoprotein Lipase (LPL) is a key enzyme in lipid metabolism that hydrolyzes triglycerides in circulating lipoproteins, primarily chylomicrons and very-low-density lipoproteins (VLDL).
Primary Expressionneurons (especially in hippocampus and cortex), astrocytes, and microglia - Regional Distribution: High expression i
PathwaysCholesterol, Glycolysis, Immune Response, Lipid Metabolism, Oxidative Phosphorylation
GeneCardsLPL
Human Protein AtlasLPL
Brain lipid homeostasisProviding energy through fatty acid oxidation
Synaptic functionSupporting membrane lipid composition
Myelin maintenanceDelivering lipids for myelin sheath integrity
NeuroprotectionModulating inflammation and oxidative stress [2]
BrainLPL is expressed in neurons (especially in hippocampus and cortex), astrocytes, and microglia
Regional DistributionHigh expression in the hippocampus, cerebral cortex, and basal ganglia
UpregulationInduced during demyelination and in response to neuronal injury
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Dementia, Diabetes
InteractionsCLOCK, SIRT1, PPARG, NLRP3, NFKB1, PPARGC1A
KG Connections258 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

LPL — Lipoprotein Lipase

gene · 590 words

APOC4 — Apolipoprotein C-IV

gene · 4687 words

substantia-nigra

brain_region · 4437 words

Glia-Neuron Crosstalk in Alzheimer's Disease

mechanism · 4121 words

TREM2 in Parkinson's Disease — Cross-Disease Therapeutic Opportunity

mechanism · 3181 words

Microglia Activation Mechanism

mechanism · 3164 words

Pathway Diagram

flowchart TD
    LPL["LPL"] -->|"catalyzes"| triglyceride["triglyceride"]
    ANGPTL4["ANGPTL4"] -.->|"inhibits"| LPL["LPL"]
    LPL["LPL"] -->|"associated with"| Diabetes["Diabetes"]
    LPL["LPL"] -->|"associated with"| Als["Als"]
    LPL["LPL"] -->|"associated with"| Aging["Aging"]
    LPL["LPL"] -->|"associated with"| Ms["Ms"]
    LPL["LPL"] -->|"expressed in"| Diabetes["Diabetes"]
    LPL["LPL"] -->|"expressed in"| Als["Als"]
    LPL["LPL"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    LPL["LPL"] -->|"interacts with"| Ms["Ms"]
    LPL["LPL"] -->|"interacts with"| Cancer["Cancer"]
    LPL["LPL"] -->|"interacts with"| Tumor["Tumor"]
    style LPL fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style triglyceride fill:#5d4400,stroke:#333,color:#e0e0e0
    style ANGPTL4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (159)

TargetRelationTypeStr
triglyceridecatalyzesbiological_process0.80
Lipid Processingmodulatesprocess0.80
Aβ Clearancemodulatesprocess0.80
lipid processingregulatesprocess0.80
NEURODEGENERATIONassociated_withprocess0.80

Incoming (99)

SourceRelationTypeStr
CTSDassociated_withgene0.70
FGF21associated_withgene0.60
HMOX1associated_withgene0.60
ALDH1A1therapeutic_targetgene0.60
SIRT1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found