Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LPL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LPL is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Alzheimer. Connected to 109 entities in the SciDEX knowledge graph.
| Gene Symbol | LPL |
| Full Name | Lipoprotein Lipase |
| Protein Type | Enzyme |
| Function | Lipoprotein Lipase (LPL) is a key enzyme in lipid metabolism that hydrolyzes triglycerides in circulating lipoproteins, primarily chylomicrons and very-low-density lipoproteins (VLDL). |
| Primary Expression | neurons (especially in hippocampus and cortex), astrocytes, and microglia - Regional Distribution: High expression i |
| Pathways | Cholesterol, Glycolysis, Immune Response, Lipid Metabolism, Oxidative Phosphorylation |
| GeneCards | LPL |
| Human Protein Atlas | LPL |
| Brain lipid homeostasis | Providing energy through fatty acid oxidation |
| Synaptic function | Supporting membrane lipid composition |
| Myelin maintenance | Delivering lipids for myelin sheath integrity |
| Neuroprotection | Modulating inflammation and oxidative stress [2] |
| Brain | LPL is expressed in neurons (especially in hippocampus and cortex), astrocytes, and microglia |
| Regional Distribution | High expression in the hippocampus, cerebral cortex, and basal ganglia |
| Upregulation | Induced during demyelination and in response to neuronal injury |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Dementia, Diabetes |
| Interactions | CLOCK, SIRT1, PPARG, NLRP3, NFKB1, PPARGC1A |
| KG Connections | 258 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
LPL["LPL"] -->|"catalyzes"| triglyceride["triglyceride"]
ANGPTL4["ANGPTL4"] -.->|"inhibits"| LPL["LPL"]
LPL["LPL"] -->|"associated with"| Diabetes["Diabetes"]
LPL["LPL"] -->|"associated with"| Als["Als"]
LPL["LPL"] -->|"associated with"| Aging["Aging"]
LPL["LPL"] -->|"associated with"| Ms["Ms"]
LPL["LPL"] -->|"expressed in"| Diabetes["Diabetes"]
LPL["LPL"] -->|"expressed in"| Als["Als"]
LPL["LPL"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
LPL["LPL"] -->|"interacts with"| Ms["Ms"]
LPL["LPL"] -->|"interacts with"| Cancer["Cancer"]
LPL["LPL"] -->|"interacts with"| Tumor["Tumor"]
style LPL fill:#4a1a6b,stroke:#333,color:#e0e0e0
style triglyceride fill:#5d4400,stroke:#333,color:#e0e0e0
style ANGPTL4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| triglyceride | catalyzes | biological_process | 0.80 |
| Lipid Processing | modulates | process | 0.80 |
| Aβ Clearance | modulates | process | 0.80 |
| lipid processing | regulates | process | 0.80 |
| NEURODEGENERATION | associated_with | process | 0.80 |
| Als | associated_with | disease | 0.75 |
| Aging | associated_with | disease | 0.75 |
| Complement | associated_with | pathway | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| Diabetes | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Diabetes | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cardiovascular | expressed_in | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Atherosclerosis | expressed_in | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Atherosclerosis | protects_against | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| Als | causes | disease | 0.65 |
| Aging | causes | disease | 0.65 |
| Diabetes | causes | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Atherosclerosis | inhibits | disease | 0.65 |
| GUSB | therapeutic_target | gene | 0.60 |
| CLOCK | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| PPARG | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| NR1D1 | expressed_in | gene | 0.60 |
| NFKB1 | activates | gene | 0.60 |
| HMOX1 | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| PPARGC1A | interacts_with | gene | 0.60 |
| PPARG | interacts_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| SYK | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CTSD | associated_with | gene | 0.70 |
| FGF21 | associated_with | gene | 0.60 |
| HMOX1 | associated_with | gene | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| FASN | activates | gene | 0.60 |
| NFKBIA | activates | gene | 0.60 |
| PGC1A | activates | gene | 0.60 |
| PER2 | expressed_in | gene | 0.60 |
| GUSB | therapeutic_target | gene | 0.60 |
| CD36 | interacts_with | gene | 0.60 |
| ABCA1 | associated_with | gene | 0.60 |
| DHCR24 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| SREBF2 | associated_with | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| TREM2 | regulates | gene | 0.60 |
| ABCA7 | regulates | gene | 0.60 |
| PPARG | regulates | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| CLUSTERIN | associated_with | gene | 0.60 |
| PICALM | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| SYK | regulates | gene | 0.60 |
| LDLR | inhibits | gene | 0.60 |
| CX3CR1 | expressed_in | gene | 0.60 |
| NCF1 | associated_with | gene | 0.60 |
| GJA1 | interacts_with | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| APOE4 | regulates | gene | 0.60 |
| CALM1 | interacts_with | gene | 0.60 |
| SLC6A1 | interacts_with | gene | 0.60 |
| TXN | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| PARKIN | regulates | gene | 0.60 |
| CD36 | regulates | gene | 0.60 |
| LDLR | regulates | gene | 0.60 |
| ADRA2A | activates | gene | 0.60 |
| ALDH1A2 | activates | gene | 0.60 |
| IDH1 | activates | gene | 0.60 |
| ITPKA | activates | gene | 0.60 |
| APOE | implicated_in | gene | 0.60 |
| APP | implicated_in | gene | 0.60 |
| BDNF | implicated_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||