gene

LPL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

243Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

LPL is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Alzheimer. Connected to 109 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LPL
Full Name	Lipoprotein Lipase
Protein Type	Enzyme
Function	Lipoprotein Lipase (LPL) is a key enzyme in lipid metabolism that hydrolyzes triglycerides in circulating lipoproteins, primarily chylomicrons and very-low-density lipoproteins (VLDL).
Primary Expression	neurons (especially in hippocampus and cortex), astrocytes, and microglia - Regional Distribution: High expression i
Pathways	Cholesterol, Glycolysis, Immune Response, Lipid Metabolism, Oxidative Phosphorylation
GeneCards	LPL
Human Protein Atlas	LPL
Brain lipid homeostasis	Providing energy through fatty acid oxidation
Synaptic function	Supporting membrane lipid composition
Myelin maintenance	Delivering lipids for myelin sheath integrity
Neuroprotection	Modulating inflammation and oxidative stress [2]
Brain	LPL is expressed in neurons (especially in hippocampus and cortex), astrocytes, and microglia
Regional Distribution	High expression in the hippocampus, cerebral cortex, and basal ganglia
Upregulation	Induced during demyelination and in response to neuronal injury
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Dementia, Diabetes
Interactions	ADRA2A, ALDH1A2, ALZHEIMER'S DISEASE, AMPK, APOE, AUTOPHAGY
KG Connections	243 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LPL — Lipoprotein Lipase

gene · 590 words

→

LPL Protein — Lipoprotein Lipase

protein · 600 words

→

Pathway Diagram

flowchart TD
    LPL["LPL"] -->|"catalyzes"| triglyceride["triglyceride"]
    ANGPTL4["ANGPTL4"] -.->|"inhibits"| LPL["LPL"]
    LPL["LPL"] -->|"associated with"| Diabetes["Diabetes"]
    LPL["LPL"] -->|"associated with"| Als["Als"]
    LPL["LPL"] -->|"associated with"| Aging["Aging"]
    LPL["LPL"] -->|"associated with"| Ms["Ms"]
    LPL["LPL"] -->|"expressed in"| Diabetes["Diabetes"]
    LPL["LPL"] -->|"expressed in"| Als["Als"]
    LPL["LPL"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    LPL["LPL"] -->|"interacts with"| Ms["Ms"]
    LPL["LPL"] -->|"interacts with"| Cancer["Cancer"]
    LPL["LPL"] -->|"interacts with"| Tumor["Tumor"]
    style LPL fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style triglyceride fill:#5d4400,stroke:#333,color:#e0e0e0
    style ANGPTL4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (153)

Target	Relation	Type	Str
NEURODEGENERATION	associated_with	process	0.80
triglyceride	catalyzes	process	0.80
lipid processing	regulates	process	0.80
Aβ Clearance	modulates	process	0.80
Lipid Processing	modulates	process	0.80
Als	associated_with	disease	0.75
Aging	associated_with	disease	0.75
lipid metabolism	regulates	process	0.70
Complement	associated_with	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Diabetes	causes	disease	0.65
Parkinson	regulates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Atherosclerosis	protects_against	disease	0.65
Diabetes	activates	disease	0.65
Als	causes	disease	0.65
Dementia	associated_with	disease	0.65
Aging	causes	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
neurodegeneration	regulates	disease	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Cholesterol	expressed_in	pathway	0.60
Lipid Metabolism	expressed_in	pathway	0.60
Synaptic Vesicle	expressed_in	pathway	0.60
GUSB	associated_with	gene	0.60
Hif-1	regulates	protein	0.60
Rb	regulates	protein	0.60
PICALM	implicated_in	gene	0.60
SORL1	implicated_in	gene	0.60
PCK1	interacts_with	gene	0.60

Incoming (90)

Source	Relation	Type	Str
TREM2	associated_with	gene	0.70
CTSD	associated_with	gene	0.70
ABCA7	regulates	gene	0.60
PPARG	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
APP	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
TREM2	regulates	gene	0.60
APOE	associated_with	gene	0.60
PARKIN	regulates	gene	0.60
CD36	regulates	gene	0.60
LDLR	inhibits	gene	0.60
LC3B	activates	gene	0.60
PER	expressed_in	gene	0.60
CALM1	interacts_with	gene	0.60
GJA1	interacts_with	gene	0.60
CX3CR1	expressed_in	gene	0.60
NCF1	associated_with	gene	0.60
APOE	regulates	gene	0.60
ADRA2A	activates	gene	0.60
ALDH1A2	activates	gene	0.60
IDH1	activates	gene	0.60
ITPKA	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
PER	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
ACC	expressed_in	gene	0.60
SREBP2	regulates	gene	0.60
HIF-1Α	regulates	gene	0.60
FGF21	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
SIRT1	inhibits	gene	0.60
FASN	activates	gene	0.60
NFKBIA	activates	gene	0.60
PGC1A	activates	gene	0.60
PER2	expressed_in	gene	0.60
GUSB	therapeutic_target	gene	0.60
CD36	interacts_with	gene	0.60
ABCA1	associated_with	gene	0.60
DHCR24	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
SREBF2	associated_with	gene	0.60
HK2	activates	gene	0.60
SYK	regulates	gene	0.60
SLC6A1	interacts_with	gene	0.60
TXN	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Spatial Transcriptomics Analysis of Alzheimer's Disease Brain Regions

neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.380

What are the optimal timing windows for TREM2 inhibition vs activation in Alzhei

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning LPL in their description or question text

No additional research found

LPL