Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about als8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | VAPB |
| Full Name | Amyotrophic Lateral Sclerosis 8 |
| Aliases | Page for ALS8 |
| Chromosome | 20q13.33 |
| Protein Type | Type III ER membrane protein |
| Function | is a genetic locus associated with familial amyotrophic lateral sclerosis (ALS). |
| Primary Expression | Ubiquitous, high in brain and spinal cord |
| Amino Acids | 243 aa |
| UniProt ID | Q9UBS4 |
| Ensembl ID | ENSG00000124194 |
| OMIM | 607348 |
| GeneCards | VAPB |
| Human Protein Atlas | VAPB |
| Associated Diseases | Neurodegeneration, Amyotrophic Lateral Sclerosis, Dementia, Als, Ms, Cardiovascular |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ALS8["ALS8"]
ALS8 -->|"implicated in"| neurodegeneration["neurodegeneration"]
ALS8 ---|"associated"| Als["Als"]
ALS8 ---|"associated"| Glaucoma["Glaucoma"]
ALS8 ---|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
ALS8 ---|"associated"| ALSIN["ALSIN"]
ALS8 ---|"associated"| ALS4["ALS4"]
ALS2["ALS2"] ---|"associated"| ALS8
FIG4["FIG4"] ---|"associated"| ALS8
FUS["FUS"] ---|"associated"| ALS8| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Glaucoma | associated_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.65 |
| ALSIN | associated_with | gene | 0.60 |
| ALS4 | associated_with | gene | 0.60 |
| ALS9 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| ALS7 | associated_with | gene | 0.60 |
| ALS10 | associated_with | gene | 0.60 |
| SOD1 | associated_with | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MOTOR NEURONS | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 0.60 |
| GENE MUTATIONS | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:ALS8 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS2 | associated_with | gene | 0.60 |
| FIG4 | associated_with | gene | 0.60 |
| FUS | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:ALS8 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||