gene

ALS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

214Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

ALS4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 92 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSETX (formerly ALS4)
Full NameSenataxin
AliasesAlsin, Alsine
Chromosome9q34.13
Protein FamilySuperfamily 1 (SF1) DNA/RNA helicases
Functionis a rare, autosomal dominant form of amyotrophic lateral sclerosis characterized by juvenile onset and relatively slow progression.
Primary ExpressionHighest in motor neurons, cerebellar Purkinje cells, hippocampal pyramidal neurons
Subcellular Localization**C-terminal Domain**: Contains a SEN1N-like domain involved in transcriptional termination
Molecular Weight185 kDa
Amino Acids678 aa
PathwaysAutophagy, Dna Damage Response
UniProt IDQ7Z6W4
NCBI Gene ID29978
Ensembl IDENSG00000183520
OMIM602433
Associated DiseasesALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, Dementia
Known Drugs/Compoundsrapamycin
InteractionsSETX, LC3, AMYOTROPHIC LATERAL SCLEROSIS, STROKE, NEURON, AND
KG Connections212 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: ALS4 — AlphaFold Q7Z6W4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Gene Page: ALS4 (SENATAXIN)

gene · 2157 words

Ferroptosis in Neurodegeneration

mechanism · 3536 words

Aging vs Neurodegeneration: Mechanistic Comparison Matrix

mechanism · 3330 words

Cellular Senescence in Neurodegeneration

mechanism · 3260 words

OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal Chain

mechanism · 2356 words

Proteostasis and ERAD Pathway in Neurodegeneration

mechanism · 2179 words

Pathway Diagram

flowchart TD
    ALS4["ALS4"] -->|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    ALS4["ALS4"] -->|"associated with"| Dementia["Dementia"]
    ALS4["ALS4"] -->|"associated with"| Als["Als"]
    ALS4["ALS4"] -->|"associated with"| Ataxia["Ataxia"]
    ALS4["ALS4"] -->|"regulates"| Ms["Ms"]
    ALS4["ALS4"] -.->|"inhibits"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    ALS4["ALS4"] -->|"therapeutic target"| Stroke["Stroke"]
    ALS4["ALS4"] -->|"therapeutic target"| Als["Als"]
    ALS4["ALS4"] -->|"associated with"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ALS4["ALS4"] -->|"associated with"| Ftd["Ftd"]
    ALS4["ALS4"] -->|"associated with"| Spinal_Muscular_Atrophy["Spinal Muscular Atrophy"]
    ALS4["ALS4"] -->|"associated with"| Stroke["Stroke"]
    style ALS4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Frontotemporal_Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ftd fill:#ef5350,stroke:#333,color:#e0e0e0
    style Spinal_Muscular_Atrophy fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (153)

TargetRelationTypeStr
Amyotrophic Lateral Sclerosisassociated_withdisease0.75
Alsassociated_withdisease0.75
ALSassociated_withdisease0.75
neurodegenerationcausesdisease0.70
AMYOTROPHIC LATERAL SCLEROSISassociated_withgene0.70

Incoming (61)

SourceRelationTypeStr
SETXcausesgene0.95
Setx Mutation C.1166T>Cbiomarker_forbiomarker0.92
SETX Mutationscausesmechanism0.90
R-Loop Levelsbiomarker_forbiomarker0.90
Mutant Setx (Leu389Ser)causesprotein0.88

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found