gene

FIG4

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This page aggregates everything SciDEX knows about FIG4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

138Connections
0Hypotheses
0Analyses
50Outgoing
47Incoming

Summary

Gene page for FIG4 associated with ALS and Charcot-Marie-Tooth disease

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🧬 Gene Info
Gene SymbolFIG4
Full NameFIG4 Phosphatase Homolog
Protein TypePhosphatase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids559 aa
PathwaysPI3K
Ensembl IDENSG00000112367
GeneCardsFIG4
Human Protein AtlasFIG4
VAC14scaffolds the PI(3,5)P2 synthesis complex with FIG4 and PIKFYVE
PIKFYVEphosphorylates PI3P to generate PI(3,5)P2
FYCO1interacts with PI3P for autophagosome-lysosome fusion
VPS34/PIK3C3class III PI3K that produces PI3P
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Ftd, Glaucoma
InteractionsC9ORF72, C9ORF72 REPEAT EXPANSION
KG Connections138 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

FIG4 — FIG4 Phosphatase Homolog

gene · 1430 words

Charcot-Marie-Tooth Disease

disease · 2858 words

FIG4 Protein

protein · 2571 words

Jean-Philippe Brandel

researcher · 1668 words

ALS2 (Alsin) Protein

protein · 1627 words

ALS2 (Alsin)

gene · 1425 words

Pathway Diagram

graph TD
    FIG4["<b>FIG4</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    FIG4 -->|"expressed in"| Amyotrophic_Lateral_Sclerosis
    Neurodegeneration{"Neurodegeneration"}
    FIG4 -->|"expressed in"| Neurodegeneration
    Dementia{"Dementia"}
    FIG4 -->|"expressed in"| Dementia
    Als{"Als"}
    FIG4 -->|"associated with"| Als
    Ms{"Ms"}
    FIG4 -->|"expressed in"| Ms
    FIG4 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    FIG4 -->|"activates"| Dementia
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    FIG4 -->|"activates"| Frontotemporal_Dementia
    Ftd{"Ftd"}
    FIG4 -->|"associated with"| Ftd
    FIG4 -->|"activates"| Neurodegeneration
    FIG4 -->|"causes"| Frontotemporal_Dementia
    FIG4 -->|"causes"| Dementia
    OPTN["OPTN"]
    OPTN -->|"associated with"| FIG4
    ALS2["ALS2"]
    ALS2 -->|"associated with"| FIG4
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| FIG4
    GAIN["GAIN"]
    GAIN -->|"expressed in"| FIG4
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"expressed in"| FIG4
    C9ORF72_REPEAT_EXPANSION["C9ORF72 REPEAT EXPANSION"]
    C9ORF72_REPEAT_EXPANSION -->|"expressed in"| FIG4
    RAB5["RAB5"]
    RAB5 -->|"expressed in"| FIG4
    CHMP2B["CHMP2B"]
    CHMP2B -->|"associated with"| FIG4
    C9ORF72 -->|"activates"| FIG4
    C9ORF72_REPEAT_EXPANSION -->|"activates"| FIG4
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"expressed in"| FIG4
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"expressed in"| FIG4
    style FIG4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (91)

TargetRelationTypeStr
Amyotrophic Lateral Sclerosisimplicated_indisease0.88
Vesicle Traffickinginvolved_inprocess0.75
Alsassociated_withdisease0.75
Amyotrophic Lateral Sclerosisexpressed_indisease0.65
Neurodegenerationexpressed_indisease0.65

Incoming (47)

SourceRelationTypeStr
ALS2associated_withgene0.70
OPTNassociated_withgene0.60
SQSTM1associated_withgene0.60
GAINexpressed_ingene0.60
C9ORF72expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found