concept

CHROMATIN REMODELING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHROMATIN REMODELING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

6Hypotheses

2Analyses

18Outgoing

33Incoming

3Experiments

4Debates

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💡 Concept Info

Name	CHROMATIN REMODELING
Key Genes/Proteins	AMYLOID, BDNF, BRD4, CREB, HDAC3, P300
Related Diseases	INFLAMMATION, OXIDATIVE STRESS, SENESCENCE
Related Pathways	DNA DAMAGE RESPONSE

Pathway Diagram

graph TD
    CHROMATIN_REMODELING["CHROMATIN REMODELING"]
    CHROMATIN_REMODELING -->|"mediates"| Smooth_Muscle_Cell_Phenotypic_["Smooth Muscle Cell Phenotypic Alterations"]
    CHROMATIN_REMODELING -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    CHROMATIN_REMODELING -->|"activates"| alcohol_use_disorder["alcohol use disorder"]
    CHROMATIN_REMODELING -->|"activates"| EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"]
    NCL["NCL"] -->|"involved_in"| CHROMATIN_REMODELING
    Histone_Acetylation["Histone Acetylation"] -->|"involved_in"| CHROMATIN_REMODELING
    STAT3["STAT3"] -->|"modulates"| CHROMATIN_REMODELING
    NUCLEOLIN["NUCLEOLIN"] -->|"involved_in"| CHROMATIN_REMODELING
    PBRM1["PBRM1"] -->|"involved_in"| CHROMATIN_REMODELING
    HDAC_Inhibitors["HDAC Inhibitors"] -->|"modulates"| CHROMATIN_REMODELING
    CLASS_I_HDACS["CLASS I HDACS"] -->|"regulates"| CHROMATIN_REMODELING
    alcohol["alcohol"] -->|"regulates"| CHROMATIN_REMODELING

Outgoing (18)

Target	Relation	Type	Str
Smooth Muscle Cell Phenotypic Alterations	mediates	phenotype	0.95
Alzheimer's Disease	associated_with	disease	0.85
alcohol use disorder	activates	disease	0.70
synaptic plasticity	regulates	process	0.70
transcriptional regulation	modulates	process	0.70
INTERNEURONS	regulates	cell_type	0.65
BDNF	inhibits	gene	0.60
BDNF	causes	gene	0.60
ASTROCYTE	regulates	cell_type	0.60
SENESCENCE	activates	phenotype	0.60
SENESCENCE	causes	phenotype	0.60
ASTROCYTE	activates	cell_type	0.60
INFLAMMATION	implicated_in	phenotype	0.55
INTERNEURONS	expressed_in	cell_type	0.55
SPERMIDINE	associated_with	drug	0.50
RAPAMYCIN	associated_with	drug	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
DNA DAMAGE RESPONSE	associated_with	pathway	0.45

Incoming (33)

Source	Relation	Type	Str
Histone Acetylation	involved_in	process	0.90
NUCLEOLIN	involved_in	protein	0.90
ATPase activity	causes	process	0.90
STAT3	modulates	protein	0.90
NCL	involved_in	protein	0.90
HDAC Inhibitors	modulates	drug	0.85
PBRM1	involved_in	protein	0.85
HSV-gB	mediates	protein	0.80
HUNTINGTIN	regulates	protein	0.80
CLASS I HDACS	regulates	enzyme	0.80
HDAC2	regulates	gene	0.70
alcohol	regulates	drug	0.70
AMYLOID	causes	protein	0.65
AMYLOID	regulates	protein	0.65
SIRT1	modifies	gene	0.65
EZH2	activates	gene	0.60
IRF3	activates	gene	0.60
STING	activates	gene	0.60
TBK1	activates	gene	0.60
P300	causes	gene	0.60
HDAC3	regulates	gene	0.60
TET2	interacts_with	gene	0.60
OXIDATIVE STRESS	regulates	phenotype	0.60
CREB	causes	gene	0.60
BRD4	inhibits	gene	0.60
TNF	targets	gene	0.60
Alzheimer	biomarker_for	disease	0.55
Autoimmune	biomarker_for	disease	0.55
Als	biomarker_for	disease	0.55
Inflammation	activates	disease	0.55
Cancer	biomarker_for	disease	0.55
Als	activates	disease	0.55
APOPTOSIS	implicated_in	process	0.35

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Chromatin Remodeling-Mediated Nutrient Sensing Restoration	0.764	neurodegeneration	Epigenetic reprogramming in aging neuron
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat	0.544	neurodegeneration	CRISPR-based therapeutic approaches for
protective chromatin remodeling defines the therapeutic wind	0.345	neurodegeneration	Are DNA methylation changes in neurodege
protective chromatin remodeling defines the therapeutic wind	0.326	neurodegeneration	Are age-related DNA methylation changes
Convergent Chromatin Remodeling Cascade (CRC)	0.000	-	Do different priming stimuli require dis

Chromatin Remodeling for Tau-Associated Gene Expression	0.000	-	4R-tau strain-specific spreading pattern

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do different priming stimuli require distinct therapeutic approaches or share co

immunology | 2026-04-08 | 8 hypotheses Top: 0.380

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Acteoside treatment in LPS-induced SALI mouse model	validation	sepsis-associated acute lung i	0.900	LPS-induced SALI mouse model	proposed	N/A
Nrf2 inhibitor ML385 mechanism validation experiment	exploratory	sepsis-associated acute lung i	0.850	RAW264.7 cells and/or mouse mo	proposed	N/A
Acteoside effects on RAW264.7 macrophage cells	exploratory	sepsis-associated acute lung i	0.850	RAW264.7 cells	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550]	Chappidi, Quail, Doll, Vogel, Aleksandro	Cell	2024	0
DNA-Origami-Armored DNA Condensates. [PMID:39075031]	Yamashita, Sato, Suzuki, Ishikawa, Takin	Chembiochem : a European journ	2024	0
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550]	Chappidi Nagaraja; Quail Thomas; Doll Si	Cell	2024	0
DNA-Origami-Armored DNA Condensates. [PMID:39075031]	Unknown	Chembiochem : a European journ	2024	0
Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313]	Boldinova, Makarova	Biochemistry. Biokhimiia	2023	0
Global identification of SWI/SNF targets reveals compensation by EP400. [PMID:37922899]	Martin BJE, Ablondi EF, Goglia C	Cell	2023	0
Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313]	Unknown	Biochemistry. Biokhimiia	2023	0
Bone remodeling: an operational process ensuring survival and bone mechanical co [PMID:35851054]	Bolamperti Simona; Villa Isabella; Rubin	Bone research	2022	0
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020	0
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therap [PMID:32873422]	Centore RC, Sandoval GJ, Soares LMM	Trends Genet	2020	0
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020	0
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020	0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020	0
Homologous recombination and the repair of DNA double-strand breaks. [PMID:29599286]	Wright, Shah, Heyer	The Journal of biological chem	2019	0
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298]	Melamed Ze'ev; López-Erauskin Jone;	Nature neuroscience	2019	0
Homologous recombination and the repair of DNA double-strand breaks. [PMID:29599286]	Unknown	The Journal of biological chem	2019	0

Debates (4)

Multi-agent debates referencing this entity

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Do different priming stimuli require distinct therapeutic approaches or share co

closed · Rounds: 4 · Score: 0.93 · 2026-04-10

Related Research

Hypotheses and analyses mentioning CHROMATIN REMODELING in their description or question text

Chromatin Remodeling for Tau-Associated Gene Expression

Score: 0.000 · unknown disease · 2026-04-28

Epigenetic modulation of tau-interacting proteins through chromatin modification Debate provenance: derived from debate