concept

CHROMATIN REMODELING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHROMATIN REMODELING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections
2Hypotheses
4Analyses
13Outgoing
11Incoming

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💡 Concept Info
NameCHROMATIN REMODELING
Key Genes/ProteinsSIRT1, AMYLOID, BDNF, P300, HDAC3, TET2
Related DiseasesSENESCENCE
Linked Hypotheses2 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

NPM1 Gene

gene · 5653 words

NRF2 Oxidative Stress Pathway

mechanism · 5315 words

williams-syndrome

disease · 5022 words

Kabuki Syndrome

disease · 4834 words

Huntington's Disease

disease · 4606 words

Pathway Diagram

graph TD
    CHROMATIN_REMODELING["CHROMATIN REMODELING"]
    CHROMATIN_REMODELING -->|"mediates"| Smooth_Muscle_Cell_Phenotypic_["Smooth Muscle Cell Phenotypic Alterations"]
    CHROMATIN_REMODELING -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    CHROMATIN_REMODELING -->|"activates"| alcohol_use_disorder["alcohol use disorder"]
    CHROMATIN_REMODELING -->|"activates"| EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"]
    NCL["NCL"] -->|"involved_in"| CHROMATIN_REMODELING
    Histone_Acetylation["Histone Acetylation"] -->|"involved_in"| CHROMATIN_REMODELING
    STAT3["STAT3"] -->|"modulates"| CHROMATIN_REMODELING
    NUCLEOLIN["NUCLEOLIN"] -->|"involved_in"| CHROMATIN_REMODELING
    PBRM1["PBRM1"] -->|"involved_in"| CHROMATIN_REMODELING
    HDAC_Inhibitors["HDAC Inhibitors"] -->|"modulates"| CHROMATIN_REMODELING
    CLASS_I_HDACS["CLASS I HDACS"] -->|"regulates"| CHROMATIN_REMODELING
    alcohol["alcohol"] -->|"regulates"| CHROMATIN_REMODELING

Outgoing (17)

TargetRelationTypeStr
INTERNEURONSregulatescell_type0.65
ASTROCYTEactivatescell_type0.60
ASTROCYTEregulatescell_type0.60
SENESCENCEactivatesphenotype0.60
SENESCENCEcausesphenotype0.60

Incoming (32)

SourceRelationTypeStr
SIRT1modifiesgene0.65
AMYLOIDcausesprotein0.65
AMYLOIDregulatesprotein0.65
P300causesgene0.60
HDAC3regulatesgene0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Chromatin Remodeling-Mediated Nutrient Sensing Restoration 0.619 neurodegeneration Epigenetic reprogramming in aging neuron
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat 0.517 neurodegeneration CRISPR-based therapeutic approaches for

Mentioning Analyses (4)

Scientific analyses that reference this entity

Do different priming stimuli create distinct chromatin landscapes or converge on

epigenetics | 2026-04-10 | 0 hypotheses

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

neurodegeneration | 2026-04-10 | 0 hypotheses

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

neurodegeneration | 2026-04-10 | 0 hypotheses

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found