protein

P62-SQSTM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P62-SQSTM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

p62/SQSTM1

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🔬 Protein Info

Gene Symbol	P62
Full Name	SQSTM1
Protein Type	Protein
Function	Cargo Recognition: UBA domain binds polyubiquitinated proteins
Molecular Weight	62 kDa
Pathways	AUTOPHAGY, Adaptive Immunity, Akt, Angiogenesis, Apoptosis
UniProt ID	Q13501
GeneCards	P62
Human Protein Atlas	P62
Associated Diseases	Aging, als, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	6-OHDA, ABCA1, ABCD3, ABCG1, ACHE, ACOD1
KG Connections	2889 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Pathway Diagram

graph TD
    P62["P62"]
    CANCER["CANCER"]
    P62 -->|"inhibits"| CANCER
    Stem_Cell["Stem Cell"]
    P62 -->|"activates"| Stem_Cell
    VAMP8["VAMP8"]
    P62 -->|"regulates"| VAMP8
    FIP200["FIP200"]
    P62 -->|"associated_with"| FIP200
    ADAM8["ADAM8"]
    P62 -->|"activates"| ADAM8
    BRCA1["BRCA1"]
    P62 -->|"associated_with"| BRCA1
    CANX["CANX"]
    P62 -->|"activates"| CANX
    KAT8["KAT8"]
    P62 -->|"associated_with"| KAT8
    NF_B["NF-KappaB"]
    P62 -->|"inhibits"| NF_B
    MITOPHAGY["MITOPHAGY"]
    P62 -->|"interacts_with"| MITOPHAGY
    ABCD3["ABCD3"]
    P62 -->|"interacts_with"| ABCD3
    NOX["NOX"]
    P62 -->|"activates"| NOX
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style CANCER fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Stem_Cell fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style VAMP8 fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style FIP200 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ADAM8 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style BRCA1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CANX fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style KAT8 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NF_B fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MITOPHAGY fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ABCD3 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NOX fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P62-SQSTM1 in their description or question text

No additional research found