protein

PARKIN-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARKIN-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

PARK2 Protein - Parkin

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	PARKIN
Full Name	PROTEIN
Chromosome	6q26
Protein Type	Ligase
Function	Parkin is a cytosolic E3 ubiquitin ligase essential for mitochondrial maintenance and quality control.
Primary Expression	AD brain - Parkin can degrade amyloid precursor protein (APP) fragments - May affect tau phosphorylation through ubiquitin-dependent pathways[@burns20
Pathways	Adaptive Immunity, Amyloid, Apoptosis, Autophagy, Cell Cycle
UniProt ID	O60260
NCBI Gene ID	5071
Ensembl ID	ENSG00000185358
GeneCards	PARKIN
Human Protein Atlas	PARKIN
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Canagliflozin, curcumin, CURCUMIN, DEFERIPRONE, EMPAGLIFLOZIN, epigallocatechin gallate
Interactions	6-OHDA, ABCD3, ACAT1, ACETYL-COA, Actin, AGING
KG Connections	2716 knowledge graph edges
Databases	GeneCards HPA STRING

Pathway Diagram

graph TD
    PARKIN["PARKIN"]
    DRP1["DRP1"]
    PARKIN -->|"associated_with"| DRP1
    NDP52["NDP52"]
    PARKIN -->|"regulates"| NDP52
    mitochondria["mitochondria"]
    PARKIN -->|"modifies"| mitochondria
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    PARKIN -->|"activates"| MITOCHONDRIAL_DNA
    PTEN["PTEN"]
    PARKIN -->|"associated_with"| PTEN
    MITOPHAGY["MITOPHAGY"]
    PARKIN -->|"causes"| MITOPHAGY
    ROS["ROS"]
    PARKIN -->|"interacts_with"| ROS
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    PARKIN -->|"treats"| NEUROINFLAMMATION
    MAP1LC3B["MAP1LC3B"]
    PARKIN -->|"co_discussed"| MAP1LC3B
    XBP1["XBP1"]
    PARKIN -->|"activates"| XBP1
    MITOCHONDRIA["MITOCHONDRIA"]
    PARKIN -->|"expressed_in"| MITOCHONDRIA
    GFAP["GFAP"]
    PARKIN -->|"co_discussed"| GFAP
    style PARKIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style DRP1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NDP52 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style mitochondria fill:#01579b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MITOCHONDRIAL_DNA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style PTEN fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MITOPHAGY fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ROS fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NEUROINFLAMMATION fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MAP1LC3B fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style XBP1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MITOCHONDRIA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GFAP fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARKIN-PROTEIN in their description or question text

No additional research found