Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EMPAGLIFLOZIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| AMPK | activates | protein | 0.80 |
| PARP1 | activates | gene | 0.65 |
| HYDROGEN PEROXIDE | protects_against | phenotype | 0.65 |
| HYDROGEN PEROXIDE | activates | phenotype | 0.65 |
| BDNF | regulates | gene | 0.65 |
| BDNF | inhibits | gene | 0.65 |
| BDNF | activates | gene | 0.65 |
| PARKIN | protects_against | gene | 0.65 |
| PARKIN | activates | gene | 0.65 |
| PARKINSON'S DISEASE | treats | disease | 0.65 |
| MEMANTINE | treats | drug | 0.65 |
| MICROGLIA | activates | cell_type | 0.65 |
| ISCHEMIA | protects_against | disease | 0.65 |
| ASTROCYTE | inhibits | cell_type | 0.65 |
| ASTROCYTE | activates | cell_type | 0.65 |
| NLRP3 INFLAMMASOME | activates | pathway | 0.65 |
| PARKINSON'S DISEASE | protects_against | disease | 0.65 |
| PARKINSON'S DISEASE | activates | disease | 0.65 |
| OXIDATIVE STRESS | activates | phenotype | 0.65 |
| OXIDATIVE STRESS | protects_against | phenotype | 0.65 |
| ISCHEMIA | inhibits | disease | 0.65 |
| MICROGLIAL ACTIVATION | inhibits | phenotype | 0.65 |
| NEUROINFLAMMATION | interacts_with | phenotype | 0.65 |
| NEUROINFLAMMATION | activates | phenotype | 0.65 |
| BLOOD-BRAIN BARRIER DISRUPTION | inhibits | phenotype | 0.65 |
| TAU | associated_with | protein | 0.50 |
| APOPTOSIS | associated_with | phenotype | 0.50 |
| DEMENTIA | associated_with | disease | 0.50 |
| AMYLOID | associated_with | protein | 0.50 |
| PARKIN | associated_with | gene | 0.45 |
| PARP1 | associated_with | gene | 0.45 |
| DAPAGLIFLOZIN | associated_with | drug | 0.45 |
| MTOR | associated_with | gene | 0.45 |
| BDNF | associated_with | gene | 0.45 |
| IL1B | associated_with | gene | 0.45 |
| IL10 | associated_with | gene | 0.45 |
| NOS2 | associated_with | gene | 0.45 |
| TNF | associated_with | gene | 0.45 |
| IL6 | associated_with | gene | 0.45 |
| NLRP3 | associated_with | gene | 0.45 |
| PI3K | associated_with | gene | 0.45 |
| AKT | associated_with | gene | 0.45 |
| RIVASTIGMINE | associated_with | drug | 0.45 |
| SUPEROXIDE | associated_with | phenotype | 0.45 |
| MITOPHAGY | associated_with | phenotype | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| MEMANTINE | associated_with | drug | 0.45 |
| AMPK | associated_with | gene | 0.45 |
| NEURONS | associated_with | cell_type | 0.45 |
| MICROGLIA | associated_with | cell_type | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DEMENTIA | protects_against | disease | 0.65 |
| DEMENTIA | inhibits | disease | 0.65 |
| ATP | activates | phenotype | 0.65 |
| TAU PHOSPHORYLATION | associated_with | phenotype | 0.50 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.50 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.50 |
| HYDROGEN PEROXIDE | associated_with | phenotype | 0.45 |
| PARKINSON'S DISEASE | associated_with | disease | 0.45 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.45 |
| MICROGLIAL ACTIVATION | associated_with | phenotype | 0.45 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
| BLOOD-BRAIN BARRIER DISRUPTION | associated_with | phenotype | 0.45 |
| ENDOTHELIAL CELLS | associated_with | cell_type | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||