Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IRON METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | IRON METABOLISM |
Knowledge base pages for this entity
graph TD
IRON_METABOLISM["IRON METABOLISM"]
IRON_METABOLISM -->|"modulates"| Ferroptosis_Sensitivity["Ferroptosis Sensitivity"]
IRON_METABOLISM -->|"involved_in"| Cancer["Cancer"]
IRON_METABOLISM -->|"involved_in"| Ferroptosis["Ferroptosis"]
IRON_METABOLISM -->|"involved_in"| Bovine_Mastitis["Bovine Mastitis"]
IRON_METABOLISM -->|"regulates"| ferroptosis["ferroptosis"]
IRON_METABOLISM -->|"regulates"| substantia_nigra_hyperechogeni["substantia nigra hyperechogenicity"]
Mitochondria["Mitochondria"] -->|"involved_in"| IRON_METABOLISM
TFR1["TFR1"] -->|"regulates"| IRON_METABOLISM
TRANSFERRIN["TRANSFERRIN"] -->|"involved_in"| IRON_METABOLISM
TRANSFERRIN_RECEPTOR_1["TRANSFERRIN RECEPTOR 1"] -->|"involved_in"| IRON_METABOLISM
HEPCIDIN["HEPCIDIN"] -->|"regulates"| IRON_METABOLISM
Hepcidin_Ferroportin_Axis["Hepcidin-Ferroportin Axis"] -->|"regulates"| IRON_METABOLISM
FERROPORTIN["FERROPORTIN"] -->|"involved_in"| IRON_METABOLISM
TRANSFERRIN_RECEPTOR_2["TRANSFERRIN RECEPTOR 2"] -->|"involved_in"| IRON_METABOLISM| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis Sensitivity | modulates | phenotype | 0.90 |
| Oxidative Stress | associated_with | process | 0.90 |
| HEMOGLOBIN | associated_with | protein | 0.88 |
| Cancer | involved_in | disease | 0.85 |
| Ferroptosis | involved_in | process | 0.85 |
| Bovine Mastitis | involved_in | disease | 0.80 |
| Staphylococcus aureus infection | involved_in | disease | 0.80 |
| Glucose Metabolism | interacts_with | process | 0.75 |
| ferroptosis | regulates | process | 0.70 |
| substantia nigra hyperechogenicity | regulates | biomarker_for | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TRANSFERRIN | involved_in | entity | 0.95 |
| TRANSFERRIN RECEPTOR 1 | involved_in | entity | 0.95 |
| HEPCIDIN | regulates | entity | 0.95 |
| FERROPORTIN | involved_in | entity | 0.90 |
| TRANSFERRIN RECEPTOR 2 | involved_in | entity | 0.90 |
| DMT1 | involved_in | entity | 0.90 |
| FERRITIN | involved_in | entity | 0.90 |
| MACROPHAGE | involved_in | entity | 0.90 |
| HEPATOCYTE | involved_in | entity | 0.90 |
| HEMOCHROMATOSIS PROTEIN | involved_in | entity | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||