protein

NETRIN-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NETRIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

19Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for Netrin-1 Protein

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🔬 Protein Info

Gene Symbol	NETRIN
Molecular Weight	70 kDa
Pathways	PI3K
GeneCards	NETRIN
Human Protein Atlas	NETRIN
Associated Diseases	Endometrial Cancer, Cancer
Interactions	UNC5B
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    NETRIN_1["NETRIN-1"]
    NETRIN_1 -->|"inhibits"| Tumour_Growth["Tumour Growth"]
    NETRIN_1 -->|"regulates"| EMT["EMT"]
    NETRIN_1 -->|"binds"| UNC5B["UNC5B"]
    NETRIN_1 -->|"inhibits"| cancer["cancer"]
    NETRIN_1 -->|"activates"| CARCINOMA["CARCINOMA"]
    NETRIN_1 -->|"activates"| EXOSOMES["EXOSOMES"]
    NETRIN_1 -->|"activates"| Endothelial_Cell["Endothelial Cell"]
    Pharmacological_Targeting["Pharmacological Targeting"] -->|"targets"| NETRIN_1
    UNC5B -->|"binds"| NETRIN_1
    ADORA2B["ADORA2B"] -->|"binds"| NETRIN_1
    late["late"] -->|"activates"| NETRIN_1
    NTN1["NTN1"] -->|"regulates"| NETRIN_1

Outgoing (19)

Target	Relation	Type	Str
Tumour Growth	inhibits	phenotype	0.95
EMT	regulates	process	0.95
UNC5B	binds	gene	0.90
Endometrial Cancer	associated_with	disease	0.90
Cancer	associated_with	disease	0.90
Endometrial Carcinoma	associated_with	disease	0.90
Endothelial Cells	activates	cell	0.90
endothelial cell exosomes	engineers	cellular_component	0.80
tumor growth	inhibits	process	0.80
EMT	inhibits	process	0.80
EXOSOMES	activates	concept	0.50
Endothelial Cell	activates	cell_type	0.50
ENDOTHELIAL	activates	concept	0.50
cancer	inhibits	disease	0.50
cancer	activates	disease	0.50
CARCINOMA	activates	disease	0.50
TUMOR	activates	disease	0.50
Hippocampus	activates	entity	0.50
GLUTAMATE	activates	concept	0.50

Incoming (6)

Source	Relation	Type	Str
Pharmacological Targeting	targets	mechanism	0.95
UNC5B	binds	gene	0.90
ADORA2B	binds	receptor	0.80
late	activates	disease	0.50
UNC5B	activates	gene	0.50
NTN1	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity