protein

PHOSPHO-TAU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHOSPHO-TAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections
0Hypotheses
2Analyses
14Outgoing
18Incoming

Summary

Phosphorylated Tau Protein

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🔬 Protein Info
Gene SymbolPHOSPHO
FunctionPhosphorylated tau (p-tau) refers to the hyperphosphorylated form of the microtubule-associated protein tau (MAPT)
GeneCardsPHOSPHO
Human Protein AtlasPHOSPHO
Associated DiseasesAlzheimer'S Disease, disease
InteractionsAPOE, SORL1, RETROMER
KG Connections32 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Novel Therapy Index

idea · 10647 words

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

Atypical Parkinsonism

disease · 6876 words

Pathway Diagram

flowchart TD
    N0["PHOSPHO-TAU"]
    N1["Neuron"]
    N0 -->|"activates"| N1
    N2["NEURONS"]
    N0 -->|"activates"| N2
    N3["AMYLOID"]
    N0 -->|"protects against"| N3
    N0 -->|"expressed in"| N3
    N4["SYNUCLEIN"]
    N0 -->|"expressed in"| N4
    N5["NEUROFIBRILLARY TANGLES"]
    N0 -->|"expressed in"| N5
    N6["ALZHEIMER"]
    N0 -->|"associated with"| N6
    N7["Alzheimer'S Disease"]
    N0 -->|"associated with"| N7
    N8["disease"]
    N0 -->|"associated with"| N8
    N9["ALZHEIMER'S"]
    N0 -->|"associated with"| N9
    N10["CEREBROSPINAL FLUID"]
    N0 -->|"associated with"| N10
    N11["APOE"]
    N11 -->|"activates"| N0
    N12["Autophagy"]
    N12 -->|"activates"| N0
    N13["SORL1"]
    N13 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N3 gene
    class N6 gene
    class N7 disease
    class N8 disease
    class N11 gene
    class N13 gene

Outgoing (14)

TargetRelationTypeStr
Neuronactivatescell_type0.50
NEURONSactivatesconcept0.50
AMYLOIDprotects_againstgene0.50
AMYLOIDexpressed_ingene0.50
SYNUCLEINexpressed_inconcept0.50

Incoming (24)

SourceRelationTypeStr
SV2Acorrelates_withprotein0.85
MICROGLIAcausescell_type0.70
MICROGLIAdestabilizescell_type0.70
NEURONStreatscell_type0.70
NEURONScausescell_type0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-12 | 0 hypotheses

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-02 | 2 hypotheses Top: 0.490

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found