concept

INSULIN SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

801Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

INSULIN SIGNALING is a concept in neurodegeneration research. Key relationships include: transports, co discussed, causes. Associated with NEURODEGENERATION. Connected to 14 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	INSULIN SIGNALING
Summary	# [Brain Insulin Signaling](/entities/brain-insulin-signaling) ## Introduction [Brain Insulin Signaling](/entities/brain-insulin-signaling) is an important component in the neurobiology of neurodegen
Key Genes/Proteins	TNF, APP, GLUT4, MAPT
Related Diseases	ALZHEIMER'S DISEASE, INSULIN RESISTANCE, NEURODEGENERATION

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    INSULIN_SIGNALING["INSULIN SIGNALING"]
    INSULIN_SIGNALING -->|"interacts"| Cholesterol["Cholesterol"]
    INSULIN_SIGNALING -->|"interacts"| Glycolysis["Glycolysis"]
    INSULIN_SIGNALING -->|"interacts"| Mtor["Mtor"]
    INSULIN_SIGNALING -->|"interacts"| Synaptic_Plasticity["Synaptic Plasticity"]
    INSULIN_SIGNALING -->|"interacts"| Nf__b["Nf-Kappab"]
    IRS1["IRS1"] -->|"regulates"| INSULIN_SIGNALING
    PI3K_Akt_mTOR["PI3K-Akt-mTOR"] -->|"interacts"| INSULIN_SIGNALING
    PI3K_Akt_mTOR_pathway["PI3K-Akt/mTOR pathway"] -->|"interacts"| INSULIN_SIGNALING
    IGF_1["IGF-1"] -->|"regulates"| INSULIN_SIGNALING
    JUN["JUN"] -->|"activates"| INSULIN_SIGNALING
    MTOR["MTOR"] -->|"activates"| INSULIN_SIGNALING
    AKT["AKT"] -->|"activates"| INSULIN_SIGNALING
    GENES["GENES"] -->|"activates"| INSULIN_SIGNALING
    Obesity["Obesity"] -->|"activates"| INSULIN_SIGNALING
    Diabetes["Diabetes"] -->|"activates"| INSULIN_SIGNALING

Outgoing (143)

Target	Relation	Type	Str
Insulin Resistance	involved_in	phenotype	0.90
Alzheimer's Disease	involved_in	disease	0.90
Parkinson's Disease	involved_in	disease	0.90
Cognitive Function	regulates	phenotype	0.90
Mitochondrial Dysfunction	regulates	process	0.90
Glucose Disposal	regulates	phenotype	0.90
NEURODEGENERATION	protects_against	process	0.88
TAU	regulates	protein	0.85
MTOR	upstream_of	gene	0.80
Insulin Resistance	causes	phenotype	0.80
Tau Hyperphosphorylation	inhibits	process	0.80
Autophagy	regulates	process	0.80
neurons	active_in	cell_type	0.80
Retinal Ganglion Cell Neuroprotection	involved_in	mechanism	0.80
neural stem cells	active_in	cell_type	0.80
Retinal Ganglion Cell	modulates	cell_type	0.75
Alzheimer's disease	associated_with	disease	0.70
astrocytes	active_in	cell_type	0.70
TNF	activates	gene	0.70
blood-brain barrier	active_in	brain_region	0.70
ALZHEIMER'S DISEASE	treats	disease	0.65
NEURONS	activates	cell_type	0.65
APP	regulates	gene	0.65
INSULIN RESISTANCE	treats	phenotype	0.65
synaptic plasticity	crosstalk_with	pathway	0.60
hippocampus	active_in	brain_region	0.60
endothelial cells	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
unfolded protein response	crosstalk_with	pathway	0.60
Cholesterol	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
MTOR	co_discussed	entity	0.50
INSULIN	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
INSULIN	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
AXON	protects_against	concept	0.50
INSULIN	protects_against	concept	0.50
Neuroprotection	protects_against	process	0.50
Pi3K/Akt	activates	pathway	0.50
disease	activates	disease	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
Pi3K/Akt	inhibits	pathway	0.50
INSULIN	inhibits	concept	0.50
PI3K/AKT/mTOR	inhibits	pathway	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50

Incoming (658)

Source	Relation	Type	Str
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
PI3K	activates	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00
Aging	activates	disease	1.00
Insulin Resistance	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
AKT	mediates	protein	0.95
GLP-1	associated_with	protein	0.95
GLP-1	promotes	protein	0.95
insulin receptor	activates	receptor	0.90
AKT	component_of	protein	0.90
MTOR	component_of	protein	0.90
GLP-1R	activates	receptor	0.90
AMPK	regulates	protein	0.90
diabetes	involves	disease	0.90
Alzheimer's disease	involves	disease	0.90
MTOR	activates	gene	0.90
AKT	activates	gene	0.90
GENES	activates	gene	0.90
Alzheimer	activates	disease	0.90
Aging	therapeutic_target	disease	0.90
AGING	activates	gene	0.90
Glp-1 Receptor Agonists	associated_with	drug	0.87
resveratrol	activates	drug	0.85
APOE4	participates_in	gene	0.85
astrocytes	active_in	cell_type	0.85
microglia	active_in	cell_type	0.85
neurons	active_in	cell_type	0.85
PI3K	participates_in	gene	0.80
neurodegeneration	involves	disease	0.80
MTOR	inhibits	gene	0.80
Obesity	activates	disease	0.80
Diabetes	activates	disease	0.80
Diabetes	contributes_to	disease	0.80
Neurodegeneration	contributes_to	disease	0.80
Cardiovascular	activates	disease	0.80
Diabetes	therapeutic_target	disease	0.80
INSULIN RESISTANCE	therapeutic_target	gene	0.80
OXIDATIVE STRESS	contributes_to	gene	0.80
AKT	regulates	gene	0.80
NEURODEGENERATION	contributes_to	gene	0.80
INSULIN RESISTANCE	contributes_to	gene	0.80
Insulin Resistance	contributes_to	disease	0.80
TAU	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
ALZHEIMER	activates	gene	0.80
ALZHEIMER'S DISEASE	activates	gene	0.80
ALZHEIMER	associated_with	gene	0.80
AMYLOID	activates	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

INSULIN SIGNALING

Understanding Entity Pages

Summary

Wiki Pages (21)

Brain Insulin Signaling

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

TREM2 Mechanism Hub

GSK-3β in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

cerebral-cortical-vasal-neurons

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Tauopathies