Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SUBSTANCE P: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SUBSTANCE P |
Knowledge base pages for this entity
graph TD
SUBSTANCE_P["SUBSTANCE P"]
SUBSTANCE_P -->|"treats"| Colitis["Colitis"]
SUBSTANCE_P -->|"suppresses"| Inflammation["Inflammation"]
SUBSTANCE_P -->|"suppresses"| Ferroptosis["Ferroptosis"]
SUBSTANCE_P -->|"inhibits"| CGAS_STING["CGAS-STING"]
SUBSTANCE_P -->|"inhibits"| cGAS_STING_Pathway["cGAS-STING Pathway"]
SUBSTANCE_P -.protects against.-> colitis["colitis"]
SUBSTANCE_P -->|"inhibits"| cGAS_STING_pathway["cGAS-STING pathway"]
NK1R["NK1R"] -->|"interacts"| SUBSTANCE_P| Target | Relation | Type | Str |
|---|---|---|---|
| Colitis | treats | disease | 0.95 |
| Colitis | associated_with | disease | 0.95 |
| Inflammation | suppresses | process | 0.95 |
| Ferroptosis | suppresses | process | 0.95 |
| CGAS-STING | inhibits | pathway | 0.95 |
| cGAS-STING Pathway | inhibits | pathway | 0.93 |
| Ferroptosis | inhibits | process | 0.91 |
| colitis | protects_against | disease | 0.90 |
| STING | inhibits | protein | 0.90 |
| ferroptosis | inhibits | phenotype | 0.90 |
| NK1R | binds | receptor | 0.90 |
| Mitochondria | protects_against | cell_type | 0.90 |
| cGAS-STING pathway | inhibits | pathway | 0.90 |
| Intestinal Barrier Function | protects_against | phenotype | 0.89 |
| Intestinal Barrier Function | associated_with | phenotype | 0.85 |
| TIMP1 | inhibits | protein | 0.70 |
| mast cells | released_by | cell_type | 0.70 |
| neurons | released_by | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||