concept

CGAS-STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS-STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

277Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CGAS-STING PATHWAY
Key Genes/Proteins	DRP1
Related Diseases	CANCER, ISCHEMIA, ALZHEIMER'S DISEASE, MITOPHAGY, INFLAMMATION
Related Pathways	IL-6-STAT3 PATHWAY, ectopic DNA detection

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CGAS_STING_PATHWAY["CGAS-STING PATHWAY"]
    style CGAS_STING_PATHWAY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CGAS_STING_PATHWAY -->|"activates"| innate_immune_response["innate immune response"]
    CGAS_STING_PATHWAY -->|"involved_in"| Innate_Immunity["Innate Immunity"]
    CGAS_STING_PATHWAY -->|"promotes"| astrocyte_senescence["astrocyte senescence"]
    CGAS_STING_PATHWAY -->|"causes"| cardiac_inflammation(cardiac inflammation)
    CGAS_STING_PATHWAY -->|"causes"| ageing_related_inflammation(ageing-related inflammation)
    CGAS_STING_PATHWAY -->|"upregulates"| PRO_INFLAMMATORY_CYTOKINES([PRO-INFLAMMATORY CYTOKINES])
    CGAS_STING_PATHWAY -.->|"inhibits"| MTOR([MTOR])
    CGAS_STING_PATHWAY -->|"promotes"| neurodegeneration["neurodegeneration"]
    CGAS_STING_PATHWAY -->|"mediates"| Proinflammatory_Response["Proinflammatory Response"]
    CGAS_STING_PATHWAY -->|"activates"| Sterile_Inflammation["Sterile Inflammation"]
    Dna["Dna"] -->|"activates"| CGAS_STING_PATHWAY
    Mitophagy["Mitophagy"] -->|"interacts"| CGAS_STING_PATHWAY
    Substance_P([Substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    Mitochondrial_DNA["Mitochondrial DNA"] -->|"activates"| CGAS_STING_PATHWAY
    substance_P([substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    pathogenic_DNA([pathogenic DNA]) -->|"activates"| CGAS_STING_PATHWAY
    PINK1([PINK1]) -.->|"inhibits"| CGAS_STING_PATHWAY
    mitochondrial_DNA([mitochondrial DNA]) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_Mitochondria(Damaged Mitochondria) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_mitochondria["Damaged mitochondria"] -->|"activates"| CGAS_STING_PATHWAY

Outgoing (136)

Target	Relation	Type	Str
ectopic DNA detection	required_for	biological_process	0.80
ALZHEIMER'S DISEASE	causes	disease	0.65
ASTROCYTES	associated_with	cell_type	0.50
PARKINSON	associated_with	disease	0.50
PARKIN	associated_with	gene	0.50
ALS	associated_with	disease	0.50
DASATINIB	associated_with	drug	0.50
QUERCETIN	associated_with	drug	0.50
ISCHEMIA	associated_with	disease	0.50
HDAC3	associated_with	gene	0.50
TUMOR CELLS	associated_with	cell_type	0.50
DIMETHYL FUMARATE	associated_with	drug	0.50
CD8+ T CELLS	associated_with	cell_type	0.50
T CELLS	associated_with	cell_type	0.50
TRASTUZUMAB	associated_with	drug	0.45
TUMOR GROWTH	associated_with	phenotype	0.45
MACROPHAGE	associated_with	cell_type	0.45
TFEB	associated_with	gene	0.45
TBK1	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
FERROPTOSIS	associated_with	phenotype	0.45
MITOPHAGY	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
ALZHEIMER	associated_with	disease	0.45
STAT3	associated_with	gene	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
IL6	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
NEURODEGENERATION	associated_with	phenotype	0.45
HUNTINGTON	associated_with	disease	0.45
PINK1	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
TAU	associated_with	protein	0.45
STROKE	associated_with	disease	0.45
SENESCENCE	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
CYTOKINES	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
STING	associated_with	gene	0.45
CGAS	associated_with	gene	0.45
MELATONIN	associated_with	drug	0.45
NECROPTOSIS	associated_with	phenotype	0.45
CXCL10	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
ASTROCYTE	associated_with	cell_type	0.45
DRP1	associated_with	gene	0.45
MACROPHAGES	associated_with	cell_type	0.45
APOPTOSIS	associated_with	phenotype	0.45
UBIQUITIN	associated_with	protein	0.45

Incoming (141)

Source	Relation	Type	Str
IL-6-STAT3 PATHWAY	regulates	pathway	0.88
CANCER	activates	disease	0.70
ISCHEMIA	regulates	disease	0.70
ISCHEMIA	activates	disease	0.70
MITOPHAGY	causes	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
TUMOR CELLS	activates	cell_type	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
NEURON	activates	cell_type	0.65
PROTEASOME DYSFUNCTION	activates	phenotype	0.65
DIMETHYL FUMARATE	activates	drug	0.65
ASTROCYTE	exacerbates	cell_type	0.65
DRP1	regulates	gene	0.65
ASTROCYTE	regulates	cell_type	0.65
APOPTOSIS	inhibits	phenotype	0.65
AUTOPHAGY	inhibits	phenotype	0.65
ASTROCYTE REACTIVITY	exacerbates	phenotype	0.65
DRP1	activates	gene	0.65
ASTROCYTE REACTIVITY	regulates	phenotype	0.65
HUNTINGTON'S DISEASE	associated_with	disease	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
PROTEASOME DYSFUNCTION	associated_with	phenotype	0.45
ASTROCYTE REACTIVITY	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CGAS-STING PATHWAY

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

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Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Necroptotic Neurons

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Vestibular Function Testing in Corticobasal Syndrome

Lipid Metabolism Dysregulation in Neurodegeneration

PBKR03

Portable Driving Simulator for PD Assessment (NCT03969927)

cGAS-STING Signaling in Parkinson's Disease

Mitochondria in Neurodegeneration

Iron Homeostasis Dysregulation in Neurodegeneration

Neuroinflammation Microglia

nct07322003

Liver-Brain Neurodegeneration Axis