Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUMOR CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TUMOR CELLS |
| Key Genes/Proteins | PI3K, ALK, LRP1, UBIQUITIN, PARP1, MTOR |
| Related Diseases | LEUKEMIA, SENESCENCE, CELL DEATH, CANCER |
| Related Pathways | CGAS-STING PATHWAY |
Knowledge base pages for this entity
graph TD
TUMOR_CELLS["TUMOR CELLS"]
TUMOR_CELLS -->|"component_of"| Lung_Adenocarcinoma["Lung Adenocarcinoma"]
TUMOR_CELLS -->|"involved_in"| Autophagy["Autophagy"]
TUMOR_CELLS -->|"interacts"| Immune_System["Immune System"]
TUMOR_CELLS -->|"interacts"| Immune_Cells["Immune Cells"]
TUMOR_CELLS -->|"activates"| PI3K["PI3K"]
TUMOR_CELLS -->|"regulates"| ALK["ALK"]
TUMOR_CELLS -->|"activates"| LRP1["LRP1"]
Bispecific_Antibodies["Bispecific Antibodies"] -->|"targets"| TUMOR_CELLS
CAR_T_therapy["CAR T therapy"] -->|"eliminates"| TUMOR_CELLS
ferroptosis["ferroptosis"] -->|"causes"| TUMOR_CELLS
EGFR["EGFR"] -->|"expressed in"| TUMOR_CELLS
MCL1["MCL1"] -->|"expressed in"| TUMOR_CELLS
Oxidative_Stress_Regulation_Ne["Oxidative Stress Regulation Network"] -->|"expressed in"| TUMOR_CELLS
FIBROBLASTS["FIBROBLASTS"] -->|"interacts"| TUMOR_CELLS| Target | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | gene | 0.65 |
| PI3K | regulates | gene | 0.65 |
| ALK | regulates | gene | 0.65 |
| LRP1 | activates | gene | 0.65 |
| UBIQUITIN | protects_against | protein | 0.65 |
| LEUKEMIA | regulates | disease | 0.65 |
| PARP1 | inhibits | gene | 0.65 |
| CGAS-STING PATHWAY | activates | pathway | 0.65 |
| SENESCENCE | activates | phenotype | 0.65 |
| CELL DEATH | causes | phenotype | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FIBROBLASTS | interacts_with | cell_type | 0.65 |
| MTOR | causes | gene | 0.65 |
| AUTOPHAGOSOMES | stabilizes | organelle | 0.65 |
| CANCER | regulates | disease | 0.65 |
| CANCER | activates | disease | 0.65 |
| MTOR | converts | gene | 0.60 |
| MTOR | implicated_in | gene | 0.55 |
| HAVCR2 | expressed_in | gene | 0.55 |
| AUTOPHAGOSOMES | associated_with | organelle | 0.50 |
| CGAS-STING PATHWAY | associated_with | pathway | 0.50 |
| STING PATHWAY | associated_with | pathway | 0.50 |
| OSIMERTINIB | associated_with | drug | 0.45 |
| NOTCH SIGNALING | associated_with | pathway | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||