concept

STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

47Outgoing

9Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	STING PATHWAY
Key Genes/Proteins	TFEB, TBK1, PARKIN
Related Diseases	IMMUNE RESPONSE, SENESCENCE, NEUROINFLAMMATION, PARKINSON
Related Pathways	NLRP3 INFLAMMASOME

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    STING_PATHWAY["STING PATHWAY"]
    STING_PATHWAY -->|"promotes"| inflammatory_cytokine_expressi["inflammatory cytokine expression"]
    STING_PATHWAY -->|"mediates"| Innate_Immune_Response["Innate Immune Response"]
    STING_PATHWAY -->|"activates"| Cortical_Motor_Neurons["Cortical Motor Neurons"]
    STING_PATHWAY -->|"activates"| Spinal_Motor_Neurons["Spinal Motor Neurons"]
    STING_PATHWAY -->|"regulates"| innate_immunity["innate immunity"]
    STING_PATHWAY -->|"promotes"| atherosclerosis["atherosclerosis"]
    STING_PATHWAY -->|"regulates"| apoptosis["apoptosis"]
    STING_PATHWAY -->|"regulates"| pyroptosis["pyroptosis"]
    DNA_Damage["DNA Damage"] -->|"activates"| STING_PATHWAY
    DNA_damage["DNA damage"] -->|"activates"| STING_PATHWAY
    cigarette_smoke["cigarette smoke"] -->|"activates"| STING_PATHWAY
    C9ORF72["C9ORF72"] -->|"activates"| STING_PATHWAY
    MTAP_deletion["MTAP deletion"] -->|"modulates"| STING_PATHWAY

Outgoing (60)

Target	Relation	Type	Str
IMMUNE RESPONSE	regulates	phenotype	0.70
DASATINIB	inhibits	drug	0.70
TFEB	activates	gene	0.65
MICROGLIA	activates	cell_type	0.65
SENESCENCE	treats	phenotype	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
TBK1	activates	gene	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
CD8+ T CELLS	interacts_with	cell_type	0.65
IMMUNE RESPONSE	implicated_in	phenotype	0.55
ASTROCYTES	associated_with	cell_type	0.50
PARKINSON	associated_with	disease	0.50
PARKIN	associated_with	gene	0.50
DASATINIB	associated_with	drug	0.50
QUERCETIN	associated_with	drug	0.50
ISCHEMIA	associated_with	disease	0.50
HDAC3	associated_with	gene	0.50
TUMOR CELLS	associated_with	cell_type	0.50
CD8+ T CELLS	associated_with	cell_type	0.50
T CELLS	associated_with	cell_type	0.50
TRASTUZUMAB	associated_with	drug	0.45
MACROPHAGES	associated_with	cell_type	0.45
MACROPHAGE	associated_with	cell_type	0.45
CANCER	associated_with	disease	0.45
STING	associated_with	gene	0.45
CGAS	associated_with	gene	0.45
TUMOR GROWTH	associated_with	phenotype	0.45
TFEB	associated_with	gene	0.45
TBK1	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
SENESCENCE	associated_with	phenotype	0.45
MOTOR NEURONS	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
NEURON	associated_with	cell_type	0.45
ALS	associated_with	disease	0.45
FERROPTOSIS	associated_with	phenotype	0.45
MITOPHAGY	associated_with	phenotype	0.45
ALZHEIMER	associated_with	disease	0.45
STAT3	associated_with	gene	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
IL6	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
HUNTINGTON	associated_with	disease	0.45
RETINA	associated_with	brain_region	0.45

Incoming (15)

Source	Relation	Type	Str
DIMETHYL FUMARATE	associated_with	drug	0.50
TUMOR MICROENVIRONMENT	associated_with	phenotype	0.50
PANCREATIC CANCER	associated_with	disease	0.45
IMMUNE RESPONSE	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
NEURODEGENERATION	associated_with	phenotype	0.45
HUNTINGTON'S DISEASE	associated_with	disease	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STING PATHWAY

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Parkinson's Disease

neuroinflammation

metal-ion-synuclein-mitochondria-axis-parkinsons

Neuroinflammation-Mitochondria Crosstalk Pathway

DNA Damage Response Impairment Pathway

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Necroptotic Neurons

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Vestibular Function Testing in Corticobasal Syndrome

Lipid Metabolism Dysregulation in Neurodegeneration

PBKR03

Portable Driving Simulator for PD Assessment (NCT03969927)

cGAS-STING Signaling in Parkinson's Disease

Mitochondria in Neurodegeneration

pink1-parkin-mitophagy-pd-causal-chain

Iron Homeostasis Dysregulation in Neurodegeneration

Neuroinflammation Microglia