concept

LEUKEMIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LEUKEMIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

716Connections

0Hypotheses

0Analyses

38Outgoing

29Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LEUKEMIA
Key Genes/Proteins	AKT, ABL1, MYC, LRP1
Related Diseases	CANCER, CHEMORESISTANCE, OXIDATIVE PHOSPHORYLATION, TUMOR, CARCINOMA
Related Pathways	JAK_STAT_PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LEUKEMIA["LEUKEMIA"]
    LEUKEMIA -->|"activates"| Epigenetic["Epigenetic"]
    LEUKEMIA -->|"activates"| Wnt["Wnt"]
    LEUKEMIA -->|"activates"| Hedgehog["Hedgehog"]
    LEUKEMIA -->|"activates"| Tgf__["Tgf-Beta"]
    LEUKEMIA -->|"inhibits"| Notch["Notch"]
    LEUKEMIA -->|"activates"| Immune_Response["Immune Response"]
    LEUKEMIA -->|"activates"| Apoptosis["Apoptosis"]
    JUN["JUN"] -->|"activates"| LEUKEMIA
    XPO1["XPO1"] -->|"expressed in"| LEUKEMIA
    NPM1["NPM1"] -.biomarker for.-> LEUKEMIA
    MCL1["MCL1"] -->|"inhibits"| LEUKEMIA
    BCL2["BCL2"] -->|"inhibits"| LEUKEMIA
    BCL2L1["BCL2L1"] -->|"inhibits"| LEUKEMIA
    LIF["LIF"] -->|"inhibits"| LEUKEMIA
    EGFR["EGFR"] -->|"activates"| LEUKEMIA

Outgoing (210)

Target	Relation	Type	Str
AKT	exacerbates	gene	0.65
CANCER	targets	disease	0.65
CHEMORESISTANCE	interacts_with	phenotype	0.65
CANCER	produces	disease	0.65
CHEMORESISTANCE	causes	phenotype	0.65
OXIDATIVE PHOSPHORYLATION	targets	phenotype	0.65
ABL1	targets	gene	0.65
ABL1	treats	gene	0.65
MYC	expressed_in	gene	0.60
LRP1	inhibits	gene	0.60
TUMOR	inhibits	disease	0.60
STEM CELLS	regulates	cell_type	0.50
FLT3	associated_with	gene	0.50
TET2	associated_with	gene	0.50
HDAC6	associated_with	gene	0.50
HDAC1	associated_with	gene	0.50
HDAC3	associated_with	gene	0.50
BRAF	associated_with	gene	0.50
HDAC2	associated_with	gene	0.45
ABL1	associated_with	gene	0.45
LRP1	associated_with	gene	0.45
TH	associated_with	gene	0.45
MACROPHAGE	co_discussed	cell_type	0.40
LYMPHOMA	co_discussed	disease	0.40
MELANOMA	co_discussed	disease	0.40
MYC	co_discussed	gene	0.40
SENESCENCE	co_discussed	process	0.40
LRP1	co_discussed	gene	0.40
METASTASIS	co_discussed	process	0.40
MACROPHAGES	biomarker_for	cell_type	0.35
MACROPHAGES	associated_with	cell_type	0.35
NOTCH SIGNALING	inhibits	process	0.35
METASTASIS	inhibits	process	0.35
MACROPHAGES	expressed_in	cell_type	0.35
STEM CELLS	expressed_in	cell_type	0.35
SIRT1	associated_with	gene	0.30
SIRT1	activates	gene	0.30
SIRT1	therapeutic_target	gene	0.30

Incoming (506)

Source	Relation	Type	Str
JAK_STAT_PATHWAY	associated_with	pathway	0.72
TUMOR CELLS	regulates	cell_type	0.65
IMATINIB	inhibits	drug	0.65
CARCINOMA	contributes_to	disease	0.60
TET2	expressed_in	gene	0.55
NILOTINIB	associated_with	drug	0.50
IMATINIB	associated_with	drug	0.50
UNFOLDED PROTEIN RESPONSE	associated_with	pathway	0.50
NOTCH SIGNALING	associated_with	pathway	0.45
JAK	co_discussed	gene	0.40
CANCER	co_discussed	disease	0.40
AKT	co_discussed	gene	0.40
HDAC2	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
IL-6	activates	gene	0.35
C1Q	biomarker_for	gene	0.35
COMPLEMENT	expressed_in	protein	0.35
C1Q	expressed_in	gene	0.35
C1Q	regulates	gene	0.35
FIBROBLASTS	activates	cell_type	0.35
C1Q	implicated_in	gene	0.35
B CELLS	activates	cell_type	0.35
HDAC2	activates	gene	0.35
CASP3	interacts_with	gene	0.35
BCL2	interacts_with	gene	0.35
BAX	interacts_with	gene	0.35
IL6	inhibits	gene	0.30
IL6	activates	gene	0.30
APOPTOSIS	causes	process	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LEUKEMIA

Understanding Entity Pages

Wiki Pages (20)

NPM1 Gene

Astrocyte Reactivity Mechanism

nf1-protein

PEN2 Gene

CNTF Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

CNTFR Gene

Gamma-Secretase Complex (γ-Secretase)

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Litronesib (LY317615/Enzastaurin)

Apoptosis Pathway in Neurodegeneration

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

ataxia-telangiectasia

Cerebellar Degeneration Pathway

RAD21 — Cohesin Complex Component in Neurodegeneration

Kyowa Kirin Co., Ltd.

IL3 (Interleukin 3)