MCL1

Understanding Entity Pages

This page aggregates everything SciDEX knows about MCL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MCL1 (Myeloid Cell Leukemia 1) is an anti-apoptotic BCL2 family protein critical for neuronal survival, mitochondrial integrity, and regulation of apoptosis in neurodegenerative diseases.

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graph TD
    MCL1["MCL1<br/>Anti-apoptotic BCL2 Family"] -->|"inhibits"| Apoptosis["Apoptosis"]
    MCL1 -->|"interacts with"| BOK["BOK"]
    MCL1 -->|"expressed in"| BCL2["BCL2"]
    MCL1 -->|"expressed in"| BCL2L1["BCL2L1/BCL-XL"]
    MCL1 -->|"regulates"| APP["APP"]
    MCL1 -->|"therapeutic target"| BAX["BAX"]
    MCL1 -->|"inhibits"| Angiogenesis["Angiogenesis"]

    BCL2 -->|"regulates"| MCL1
    APP -->|"regulates"| MCL1
    CTSD["CTSD"] -->|"inhibits"| MCL1

    MCL1 -->|"implicated in"| AD["Alzheimer's Disease"]
    MCL1 -->|"implicated in"| ALS["ALS"]
    MCL1 -->|"associated with"| Cancer["Cancer"]
    MCL1 -->|"implicated in"| HCC["Hepatocellular Carcinoma"]

    style MCL1 fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style Apoptosis fill:#f39c12,stroke:#e67e22,color:#e0e0e0
    style AD fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style ALS fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style Cancer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0