Cannot Generate Hypotheses

graph TD
    LGALS3__galectin_3_["LGALS3 (galectin-3)"] -->|promotes| lysosomal_quality_control["lysosomal quality control"]
    cellular_stress["cellular stress"] -->|causes| LGALS3_upregulation["LGALS3 upregulation"]
    TDP_43_pathology["TDP-43 pathology"] -->|causes| cognitive_decline_in_Alzh["cognitive decline in Alzheimer's patients"]
    lecanemab_donanemab["lecanemab/donanemab"] -->|promotes| amyloid_clearance["amyloid clearance"]
    alpha_synuclein["alpha_synuclein"] -->|associated with| neurodegeneration["neurodegeneration"]
    A_42["AΒ42"] -->|associated with| neurodegeneration_1["neurodegeneration"]
    LGALS3__galectin_3__2["LGALS3 (galectin-3)"] -->|promotes| cross_nucleation_at_damag["cross-nucleation at damaged endolysosomal membranes"]
    endolysosomal_membrane_da["endolysosomal membrane damage"] -->|enables| cross_seeding_of_aggregat["cross-seeding of aggregation-prone proteins"]
    LGALS3__galectin_3__3["LGALS3 (galectin-3)"] -->|promotes| amyloid_plaque_pathology["amyloid plaque pathology"]
    steric_zipper_hexapeptide["steric zipper hexapeptide inhibitors"] -.->|inhibits| cross_seeding_between_amy["cross-seeding between amyloidogenic proteins"]
    steric_zipper_motifs["steric zipper motifs"] -->|promotes| amyloid_nucleation["amyloid nucleation"]
    traumatic_brain_injury["traumatic brain injury"] -->|increases| cross_disease_protein_agg["cross-disease protein aggregation risk"]
    style LGALS3__galectin_3_ fill:#4fc3f7,stroke:#333,color:#000
    style lysosomal_quality_control fill:#4fc3f7,stroke:#333,color:#000
    style cellular_stress fill:#4fc3f7,stroke:#333,color:#000
    style LGALS3_upregulation fill:#4fc3f7,stroke:#333,color:#000
    style TDP_43_pathology fill:#ef5350,stroke:#333,color:#000
    style cognitive_decline_in_Alzh fill:#ef5350,stroke:#333,color:#000
    style lecanemab_donanemab fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_clearance fill:#4fc3f7,stroke:#333,color:#000
    style alpha_synuclein fill:#4fc3f7,stroke:#333,color:#000
    style neurodegeneration fill:#ef5350,stroke:#333,color:#000
    style A_42 fill:#4fc3f7,stroke:#333,color:#000
    style neurodegeneration_1 fill:#ef5350,stroke:#333,color:#000
    style LGALS3__galectin_3__2 fill:#4fc3f7,stroke:#333,color:#000
    style cross_nucleation_at_damag fill:#4fc3f7,stroke:#333,color:#000
    style endolysosomal_membrane_da fill:#4fc3f7,stroke:#333,color:#000
    style cross_seeding_of_aggregat fill:#4fc3f7,stroke:#333,color:#000
    style LGALS3__galectin_3__3 fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_plaque_pathology fill:#ef5350,stroke:#333,color:#000
    style steric_zipper_hexapeptide fill:#4fc3f7,stroke:#333,color:#000
    style cross_seeding_between_amy fill:#4fc3f7,stroke:#333,color:#000
    style steric_zipper_motifs fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_nucleation fill:#4fc3f7,stroke:#333,color:#000
    style traumatic_brain_injury fill:#ef5350,stroke:#333,color:#000
    style cross_disease_protein_agg fill:#ef5350,stroke:#333,color:#000