Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PROTEIN_AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| alzheimer_disease | associated_with | disease | 0.85 |
| neuronal loss | causes | unknown | 0.85 |
| alzheimers | associated_with | disease | 0.85 |
| tauopathy | causes | disease | 0.70 |
| NEURODEGENERATIVE_DISEASES | contributes_to | disease | 0.64 |
| NEURODEGENERATION | causes | phenotype | 0.64 |
| BRAIN | expressed_in | brain_region | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP70 | inhibits | protein | 0.95 |
| PROTEIN_FOLDING | inhibits | phenotype | 0.90 |
| SOD1 | causes | gene | 0.90 |
| alzheimer_disease | involved_in | disease | 0.80 |
| GCase | modulates | protein | 0.80 |
| glymphatic_clearance | prevents | mechanism | 0.80 |
| NNMT | causes | gene | 0.80 |
| PROTEIN_MISFOLDING | causes | phenotype | 0.72 |
| oxidative_stress | associated_with | phenotype | 0.70 |
| HSP90 | regulates | protein | 0.70 |
| TFEB | inhibits | gene | 0.70 |
| phase_separation | associated_with | process | 0.70 |
| Lysosomal dysfunction | causes | phenotype | 0.70 |
| Glycosaminoglycans | causes | drug | 0.70 |
| CLU | decreases_risk | gene | 0.70 |
| condensate_formation | associated_with | mechanism | 0.70 |
| ER_STRESS | causes | phenotype | 0.64 |
| TREM2_protein | inhibits | protein | 0.60 |
| transglutaminase-2 | promotes | protein | 0.60 |
| mitochondria | associated_with | cell_type | 0.60 |
| ubiquitin_proteasome_system | inhibits | pathway | 0.60 |
| autophagy | inhibits | pathway | 0.60 |
| ER_STRESS | activates | phenotype | 0.56 |
| stress_granule | promotes | process | 0.50 |
| MEMBRANE DAMAGE | increases_risk | phenotype | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-complement-amyloid axis as therapeutic target for prot | 0.550 | unknown | - |
| Protein Aggregation-Epigenetic Stress Response Modulation | 0.000 | - | Epigenetic clocks and biological aging i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.895
drug discovery | 2026-04-09 | 7 hypotheses Top: 0.455
neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.390
neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.455
neurodegeneration | 2026-04-08 | 7 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.65 · 2026-04-25
closed · Rounds: 4 · Score: 0.70 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 7 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.94 · 2026-04-10
closed · Rounds: 4 · Score: 0.86 · 2026-04-10
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
closed · Rounds: 4 · Score: 0.53 · 2026-04-06
closed · Rounds: 4 · Score: 0.71 · 2026-04-02
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning PROTEIN_AGGREGATION in their description or question text
No additional research found