concept

PHB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

432Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PHB2
Key Genes/Proteins	PINK1, PRKN, UBQLN2, TDP-43
Related Diseases	Cancer Cell Growth, Alzheimer, Als, Dementia, Parkinson
Related Pathways	PINK1-PRKN-Dependent Mitophagy, autophagy pathway, ubiquitin-proteasome, apoptosis pathway
Linked Hypotheses	1 hypotheses

Wiki Pages (12)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PHB2["PHB2"]
    style PHB2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PHB2 -->|"interacts"| Alzheimer["Alzheimer"]
    PHB2 -->|"interacts"| Als["Als"]
    PHB2 -->|"interacts"| Dementia["Dementia"]
    PHB2 -->|"interacts"| Parkinson["Parkinson"]
    PHB2 -.->|"inhibits"| Aging["Aging"]
    PHB2 -.->|"degrades"| Cardiovascular["Cardiovascular"]
    PHB2 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PHB2 -->|"studied_in"| neurodegeneration["neurodegeneration"]
    PHB2 -->|"interacts"| UBIQUITIN([UBIQUITIN])
    PEX3([PEX3]) -->|"interacts"| PHB2
    PARL([PARL]) -->|"interacts"| PHB2
    BNIP3([BNIP3]) -->|"interacts"| PHB2
    OPTINEURIN([OPTINEURIN]) -->|"interacts"| PHB2
    NLRP3([NLRP3]) -->|"interacts"| PHB2
    G3BP1([G3BP1]) -->|"interacts"| PHB2
    PTEN([PTEN]) -->|"interacts"| PHB2
    DISC1([DISC1]) -->|"interacts"| PHB2
    PRESENILIN([PRESENILIN]) -->|"interacts"| PHB2
    MFN1([MFN1]) -->|"interacts"| PHB2

Outgoing (200)

Target	Relation	Type	Str
PINK1	associated_with	protein	0.95
PINK1-PRKN-Dependent Mitophagy	mediates	pathway	0.95
PRKN	mediates	protein	0.90
Cancer Cell Growth	associated_with	phenotype	0.85
autophagy pathway	participates_in	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
TDP-43	associated_with	gene	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Aging	degrades	disease	0.65
Cardiovascular	degrades	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
UBIQUITIN	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
COX4I1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60

Incoming (232)

Source	Relation	Type	Str
FL3	inhibits	compound	0.90
h-8bd89d90	targets_gene	hypothesis	0.90
UBQLN2	interacts_with	gene	0.80
DNAJB6	protects_against	gene	0.65
PEX3	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
TOMM20	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
COX4I1	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
CTSD	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MACF1	associated_with	gene	0.60
ATM	activates	gene	0.60
BCL2	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption	0.384	neurodegeneration	Protein aggregation cross-seeding across

Mentioning Analyses (1)

Scientific analyses that reference this entity

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.488

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2-Medi [PMID:41572443]	Xu Y, Sun Y, Zhou X, Song K, Yin C et al	Adv Sci (Weinh)	2026	0
Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiol [PMID:41666677]	Shao Z, Yang X, Wang B, Wang X, Zhao D e	Redox Biol	2026	0
Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendel [PMID:41896191]	Zhang B, Li Y, Ding B, Li X, Lu Y	J Cell Mol Med	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
Efficient PHB2 (prohibitin 2) exposure during mitophagy depends on VDAC1 (voltag [PMID:39513197]	["Roy M", "Nandy S", "Marchesan E", "Ban	Autophagy	2025	0
Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related disea [PMID:39113560]	Di Rienzo M, Romagnoli A, Refolo G, Vesc	Autophagy	2024	0
Current opinions on mitophagy in fungi. [PMID:35793406]	Shen ZF, Li L, Zhu XM, Liu XH, Klionsky	Autophagy	2023	0
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419]	Persson RM, Tellnes K, Hoven H, Haaverst	Anaesthesia reports	2022	0
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270]	Fujiya Y, Harada T, Sugawara Y, Akeda Y,	Scientific reports	2021	0
The expression of PHB2 in the cochlea: Possible relation to age-related hearing [PMID:34435719]	["Yu X", "Guan M", "Shang H", "Teng Y",	Cell biology international	2021	0
Massive Hemoptysis and Recurrent Infective Endocarditis in Intravenous Drug user [PMID:33154920]	Almutairi MD, El-Ghoneimy YA, Alghamdi A	Journal of the Saudi Heart Ass	2020	0
Evaluation of care coordination among healthy community-dwelling older adults fi [PMID:31296608]	Kean T	Evidence-based nursing	2020	0
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700]	Helmuth B, Leichter JJ, Rotjan RD, Casti	Scientific data	2020	0
Prohibitin levels regulate OMA1 activity and turnover in neurons. [PMID:31819158]	["Anderson C", "Kahl A", "Fruitman H", "	Cell death and differentiation	2020	0
Multiplexed orthogonal genome editing and transcriptional activation by Cas12a. [PMID:30559432]	Breinig M, Schweitzer AY, Herianto AM, R	Nature methods	2019	0
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients [PMID:30078747]	Kahles A, Lehmann KV, Toussaint NC, Hüse	Cancer cell	2018	0
Macrophage migration inhibitory factor downregulation: a novel mechanism of resi [PMID:28218903]	Castro BA, Flanigan P, Jahangiri A, Hoff	Oncogene	2017	0
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. [PMID:28017329]	["Wei Y", "Chiang W", "Sumpter R", "Mish	Cell	2017	0
Remediation of textile effluents by membrane based treatment techniques: a state [PMID:25261752]	Dasgupta J, Sikder J, Chakraborty S, Cur	Journal of environmental manag	2015	0

PHB2

Understanding Entity Pages

Wiki Pages (12)

Mitochondrial Support Strategies for CBS/PSP

Protein Aggregation in Neurodegeneration

Protein Aggregation in Neurodegenerative Disease Comparison

Protein Aggregation and Misfolding in Neurodegeneration

Cross-Disease Therapeutic Targets in 4R-Tauopathies

Mitochondrial Dynamics Modulators for Neurodegenerative Diseases

Mitochondrial Biogenesis Inducers

EED

UBQLN2 Protein (Ubiquilin-2)

UBQLN2 Protein

Mitochondrial Therapeutics