disease

traumatic brain injury

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about traumatic brain injury: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1493Connections

0Hypotheses

2Analyses

37Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Animal	Controlled cortical impact (CCI) model in APP/PS1 mice vs WT mice
Cellular	Neuronal and microglial cultures from TBI-conditioned media exposure
Human	Retrospective cohort of TBI patients with longitudinal biomarkers
Associated Genes	PTEN, TNF, ROS, ALS, TREM2, HMGB1, CXCR1, CX3CL1
Therapeutic Agents	ACT001, rapamycin, quercetin
KG Connections	273 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    traumatic_brain_injury["traumatic brain injury"] -->|"affects"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    traumatic_brain_injury["traumatic brain injury"] -->|"affects"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    traumatic_brain_injury["traumatic brain injury"] -->|"affects"| cortex["cortex"]
    style cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    traumatic_brain_injury["traumatic brain injury"] -->|"involves"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    traumatic_brain_injury["traumatic brain injury"] -->|"involves"| NF_kB_signaling["NF-kB signaling"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    traumatic_brain_injury["traumatic brain injury"] -->|"affects"| blood_brain_barrier["blood-brain barrier"]
    style blood_brain_barrier fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    traumatic_brain_injury["traumatic brain injury"] -->|"involves"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PSMD14["PSMD14"] -->|"therapeutic target"| traumatic_brain_injury["traumatic brain injury"]
    style PSMD14 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    UCH_L1["UCH-L1"] -->|"biomarker for"| traumatic_brain_injury["traumatic brain injury"]
    style UCH_L1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    BERGENIN["BERGENIN"] -->|"attenuates"| traumatic_brain_injury["traumatic brain injury"]
    style BERGENIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SHH["SHH"] -->|"protects against"| traumatic_brain_injury["traumatic brain injury"]
    style SHH fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    STING["STING"] -->|"activates"| traumatic_brain_injury["traumatic brain injury"]
    style STING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style traumatic_brain_injury fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (352)

Target	Relation	Type	Str
microglia	affects	cell_type	0.90
neurons	affects	cell_type	0.90
cortex	affects	brain_region	0.90
necroptosis	involves	pathway	0.80
NF-kB signaling	involves	pathway	0.80
blood-brain barrier	affects	brain_region	0.80
unfolded protein response	involves	pathway	0.80
pyroptosis	involves	pathway	0.80
apoptosis pathway	involves	pathway	0.80
neural stem cells	affects	cell_type	0.80
autophagy pathway	involves	pathway	0.80
ubiquitin-proteasome	involves	pathway	0.80
PI3K-AKT-mTOR signaling	involves	pathway	0.80
autophagy	inhibits	process	0.70
neuroinflammation	causes	process	0.70
mitophagy	associated_with	process	0.70
microglia	activates	cell_type	0.70
white matter	affects	brain_region	0.70
hippocampus	affects	brain_region	0.70
synaptic plasticity	involves	pathway	0.60
glymphatic clearance	involves	pathway	0.60
spinal cord	affects	brain_region	0.60
ferroptosis	involves	pathway	0.60
oxidative stress response	involves	pathway	0.60
oligodendrocytes	affects	cell_type	0.60
astrocytes	affects	cell_type	0.60
endothelial cells	affects	cell_type	0.60
mitochondrial function	involves	pathway	0.60
blood-brain barrier	involves	pathway	0.60
axon	disrupts	organelle	0.60
endosome	disrupts	organelle	0.60
temporal lobe	affects	brain_region	0.60
JAK-STAT signaling	involves	pathway	0.60
MAPK signaling	involves	pathway	0.60
TGF-beta signaling	involves	pathway	0.60
senescence	involves	pathway	0.60
complement cascade	involves	pathway	0.60

Incoming (1141)

Source	Relation	Type	Str
PSMD14	therapeutic_target	protein	0.90
UCH-L1	biomarker_for	protein	0.88
SHH	protects_against	protein	0.80
STING	activates	gene	0.80
SQSTM1	biomarker_for	protein	0.75
APOE4	interacts_with	gene	0.75
miR-124-3p	protects_against	process	0.70
PTEN	associated_with	protein	0.70
ACT001	treats	drug	0.70
mitophagy	associated_with	process	0.70
PTEN	regulates	protein	0.70
AQP4	expressed_in	gene	0.70
TNF	associated_with	gene	0.70
ALS	associated_with	gene	0.70
NLRP3	inhibits	gene	0.70
NLRP3	regulates	gene	0.70
APOE	associated_with	gene	0.70
LC3	activates	gene	0.70
PI3K	activates	gene	0.70
ROS	activates	gene	0.70
NLRP3	targets	gene	0.70
STING	regulates	gene	0.70
DNA	activates	gene	0.70
AMPK	activates	gene	0.70
ALS	causes	gene	0.70
TREM2	protects_against	protein	0.60
ROS	associated_with	gene	0.60
GFAP	expressed_in	gene	0.60
RIPK3	treats	gene	0.60
ALS	treats	gene	0.60
RIPK1	treats	gene	0.60
AKT	inhibits	gene	0.60
AKT	regulates	gene	0.60
GFAP	treats	gene	0.60
BNIP3	inhibits	gene	0.60
BNIP3	regulates	gene	0.60
SLC17A7	promotes	gene	0.60
CHMP4B	activates	gene	0.60
CHMP4B	regulates	gene	0.60
CHMP4B	protects_against	gene	0.60
CHMP4B	promotes	gene	0.60
TNF	activates	gene	0.60
TNF	treats	gene	0.60
RNA	treats	gene	0.60
NLRP3	activates	gene	0.60
TLR4	activates	gene	0.60
TLR4	inhibits	gene	0.60
TLR4	regulates	gene	0.60
NLRP3	protects_against	gene	0.60
TLR4	protects_against	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605

What molecular mechanisms explain how KCNJ2 inhibition mitigates TBI-induced neu

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

traumatic brain injury

Understanding Entity Pages

Wiki Pages (21)