gene 2,204 words KG: FOXP3 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammationevidence:strong
Contents

FOXP3 (Forkhead Box P3)

🧬 Gene Info
Gene SymbolFOXP3
Full NameFOXP3 (Forkhead Box P3)
ChromosomeXp11.23
Protein TypeTranscription Factor
Target ClassTranscription Factor
FunctionTranscription factor modulation - no direct small molecule binding
Mechanism of ActionTranscription factor modulation - no direct small molecule binding
DruggabilityLow (0.35)
Clinical StagePhase I
Amino Acids431 aa
PathwaysApoptosis, Complement, Hedgehog, Immune Response, Mtor
UniProt IDA0A494BZV0
NCBI Gene IDSearch NCBI
GeneCardsFOXP3
Human Protein AtlasFOXP3
Associated DiseasesALZHEIMER, Als, Autoimmune, Cancer, Carcinoma
Known Drugs/Compoundspaeoniflorin, Paeoniflorin
InteractionsTGFB1, TNF, STAT3, STAT6, APOE, CCR6
SciDEX TargetView Target Profile (2 clinical trials)
KG Connections515 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ
Score: 0.61
Ocular Immune Privilege Extension
Score: 0.47

Knowledge Graph (12 edges)

FOXP3 associated_with neurodegeneration
FOXP3 interacts_with TGFB1
FOXP3 co_discussed TNFA
FOXP3 co_discussed PPARGC1A
FOXP3 co_discussed PRKAA1
FOXP3 co_discussed NR3C1
FOXP3 co_discussed DRD2
FOXP3 co_discussed CHR2
FOXP3 co_discussed CLOCK
FOXP3 co_discussed CRH