Contents

GJA1

🧬 Gene Info

Gene Symbol	GJA1
Full Name	Gap Junction Protein Alpha 1
Chromosome	6q22.31
Protein Family	Connexin family (21 members in humans)
Protein Type	Channel
Target Class	Ion Channel
Function	Connexin-43 forms gap junction channels enabling direct cell-to-cell transfer of ions (Ca²+, K+), small metabolites (ATP, glucose, glutamate), and signaling molecules.
Mechanism of Action	Small molecule modulator of gap junction channel activity
Druggability	Low (0.36)
Clinical Stage	Phase II
Molecular Weight	43 kDa
Pathways	Autophagy, Blood-brain barrier function, Nf-Κb, Oxidative Stress, Proteasome
UniProt ID	P17302
NCBI Gene ID	2697
Ensembl ID	ENSG00000152661
OMIM	121014
GeneCards	GJA1
Human Protein Atlas	GJA1
Associated Diseases	Alzheimer, Alzheimer's Disease, Amyloidosis, Cardiac, Chronic Non-Healing Wounds
Known Drugs/Compounds	Bleomycin, Gap26
Interactions	ABCA1, ACTB, Actin, ACTR2, ACTR3, AKT
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Astroglial Gap Junction Coordination via Connexin- Astrocytic Connexin-43 Upregulation Enhances Neuro CX43 hemichannel engineering enables size-selectiv
KG Connections	702 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph