concept

LOXL1-4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOXL1-4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

1Analyses

43Outgoing

36Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LOXL1-4
Key Genes/Proteins	LOX, LOX/LOXL1-4
Related Diseases	Cancer, Ms, Tumor, Als, Glioma

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LOXL1_4["LOXL1-4"]
    style LOXL1_4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    LOXL1_4 -->|"regulates"| Cancer["Cancer"]
    LOXL1_4 -->|"target for"| Ms["Ms"]
    LOXL1_4 -->|"target for"| Tumor["Tumor"]
    LOXL1_4 -->|"regulates"| Als["Als"]
    LOXL1_4 -->|"target for"| Glioma["Glioma"]
    LOXL1_4 -->|"regulates"| ALS["ALS"]
    LOXL1_4 -->|"interacts"| LOX([LOX])
    LOXL1_4 -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
    h_82922df8["h-82922df8"] -->|"targets"| LOXL1_4
    LOX -->|"interacts"| LOXL1_4
    GENES([GENES]) -->|"target for"| LOXL1_4
    LOX_LOXL1_4([LOX/LOXL1-4]) -->|"regulates"| LOXL1_4
    CANCER([CANCER]) -->|"regulates"| LOXL1_4
    LOXL3([LOXL3]) -->|"target for"| LOXL1_4
    LOXL1([LOXL1]) -->|"regulates"| LOXL1_4

Outgoing (43)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Glioma	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Als	implicated_in	disease	0.65
neurodegeneration	associated_with	disease	0.64
LOX	interacts_with	gene	0.64
neurodegeneration	implicated_in	disease	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
LOX	stabilizes	gene	0.60
LOX	regulates	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
Lipid Metabolism	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Immune Response	associated_with	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
CANCER	regulates	gene	0.60
Lipid Metabolism	implicated_in	pathway	0.60
Immune Response	implicated_in	pathway	0.60
GENES	expressed_in	gene	0.60
LOXL2	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	regulates	gene	0.60
LOXL3	expressed_in	gene	0.60
LOXL1	regulates	gene	0.60
LOXL3	stabilizes	gene	0.60
LR.LOXL3	regulates	gene	0.60
LOXL1	stabilizes	gene	0.60
Macrophage	expressed_in	cell_type	0.55
T Cell	expressed_in	cell_type	0.55
OXIDATIVE STRESS	involved_in	pathway	0.55
Nrf2 / oxidative stress response	participates_in	pathway	0.50
HCRTR1	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
LOX	co_discussed	gene	0.40
SDC1	co_discussed	gene	0.40
PDGFRB	co_discussed	gene	0.40
GJA1	co_discussed	gene	0.40
KCNK2	co_discussed	gene	0.40

Incoming (36)

Source	Relation	Type	Str
h-82922df8	targets_gene	hypothesis	0.90
h-82922df8	targets	hypothesis	0.80
LOX	interacts_with	gene	0.64
LOX	regulates	gene	0.60
LOX	associated_with	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
LOX	stabilizes	gene	0.60
LOX/LOXL1-4	associated_with	entity	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	expressed_in	gene	0.60
CANCER	regulates	gene	0.60
LOXL3	therapeutic_target	gene	0.60
LOXL1	regulates	gene	0.60
AND	regulates	gene	0.60
LOXL2	therapeutic_target	gene	0.60
LOXL3	associated_with	gene	0.60
LOXL1	associated_with	gene	0.60
LR.LOXL3	implicated_in	gene	0.60
AND	implicated_in	gene	0.60
LOXL3	expressed_in	gene	0.60
LOXL1	stabilizes	gene	0.60
LR.LOXL3	regulates	gene	0.60
LOXL3	stabilizes	gene	0.60
cancer	regulates	disease	0.50
LOX	co_mentioned_with	gene	0.50
AQP1	co_discussed	gene	0.40
KCNK2	co_discussed	gene	0.40
GJA1	co_discussed	gene	0.40
HCRTR2	co_discussed	gene	0.40
HCRTR1	co_discussed	gene	0.40
LOX	co_discussed	gene	0.40
PDGFRB	co_discussed	gene	0.40
SDC1	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
LOX	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LOXL1-4

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Sulforaphane and Nrf2 Activation for Neuroprotection

DNA Damage Response in Corticobasal Syndrome

ASC (PYCARD)

RAN Gene

Targeted Protein Degradation (PROTACs)

Tau-Targeted Therapeutics

Therapeutic Antibody Comparison Matrix

NRF2 Gene

nadph-oxidase-inhibitors

Tau Aggregation Inhibitors

NRF2 — Nuclear Factor Erythroid 2-Related Factor 2

Prostaglandin and Eicosanoid Signaling in CBS/PSP

Kinase and Phosphatase Therapeutic Target Matrix

Section 193 Advanced Integrated Cell Stress Response Therapy in CBS/PSP

ACE Protein

nrf2-activators-parkinsons-disease

Phagocytosis Modulation Therapy