| Gene Symbol | HSPA1A |
| Full Name | Heat Shock 70 kDa Protein 1A (Hsp70-1A) |
| Aliases | HSP70-1A, HSP70, Hsp70 |
| Protein Family | Hsp70 family |
| Protein Type | Chaperone |
| Target Class | Chaperone |
| Function | Small molecule activators or allosteric modulators of chaperone function |
| Mechanism of Action | Small molecule activators or allosteric modulators of chaperone function |
| Subcellular Localization | Cytoplasm, Nucleus, Cell membrane |
| Druggability | Medium (0.46) |
| Clinical Stage | Phase III |
| Molecular Weight | ~70 kDa |
| Pathways | Akt, Chaperone, ERK/JNK Pathway, Erk/Jnk Pathway, Lipid Metabolism |
| UniProt ID | P0DMV8 |
| GeneCards | HSPA1A |
| Human Protein Atlas | HSPA1A |
| Associated Diseases | AD, AGE_RELATED_DISEASES, Aging, ALI, Als |
| Known Drugs/Compounds | Bifunctional PROTACs, KNK437, RN5S, Trna |
| Interactions | ACSL4, ager, AGER, AGING, AIF1, AKT |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Proteostasis Enhancement via APOE Chaperone Target Heat Shock Protein 70 Disaggregase Amplification Hsp70-based therapy to prevent lysosomal membrane (+7 more) |
| KG Connections | 949 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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