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biomarker 2,202 words KG: dementia 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Dementia with Lewy Bodies Biomarkers

🔬 Protein Info
Gene SymbolDementia
Accurate diagnosisClinical diagnostic accuracy for DLB is only ~50-80%, biomarkers improve this significantly
Differential diagnosisHelps distinguish DLB from AD, PDD, and other dementias
Disease stagingBiomarkers can track disease progression and severity
Treatment selectionguides medication choices (e.g., cholinesterase inhibitors, antipsychotic sensitivity)
Clinical trial enrichmentEnables identification of appropriate patient populations
Prognostic assessmentPredicts cognitive decline rate and survival outcomes
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
KG Connections2605 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.57ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.80Noradrenergic-Tau Propagation Blockade
Score: 0.69TREM2-Dependent Microglial Senescence Transition
Score: 0.84Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.82

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40Sex Differences in Alzheimer's Disease — mechanisms and ther
clinical · proposed · Score: 0.40

See Also (4)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_withABCD3 Gene
gene · KG edge: activatesABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: interacts_withABCA7 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

dementia associated_with neurodegeneration
Alzheimer's disease causes dementia
Tirzepatide protects_against dementia
vascular dysfunction causes dementia
Alzheimer's disease associated_with dementia
SPP1 implicated_in dementia
G3BP1 implicated_in dementia
ALS implicated_in dementia
LC3 implicated_in dementia
TOLLIP implicated_in dementia

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