biomarker 1,963 words KG: NEURODEGENERATION 2026-03-26
kind:biomarkersection:biomarkersstate:published
Contents

MicroRNA (miRNA) Biomarkers in Neurodegenerative Disease

🔬 Protein Info
Gene SymbolNEURODEGENERATION
Aliasesneurodegeneration
Aβ/tau pathologyDownregulation of neuronal miR-9, miR-29 family members
α-Synuclein aggregationmiR-7, miR-153 target SNCA mRNA and regulate translation
NeuroinflammationmiR-155, miR-146a upregulated in activated microglia via NF-κB pathway
Mitochondrial dysfunctionmiR-30 family downregulated in PD affects mitochondrial biogenesis
TDP-43 pathologymiR-9, miR-132 dysregulation in ALS/FTD
Associated DiseasesALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/CompoundsQUERCETIN, RAPAMYCIN, METFORMIN, Cgmp, PIOGLITAZONE, MEMANTINE
InteractionsALZHEIMER'S DISEASE, P62, SYNAPTIC PRUNING, FERROPTOSIS, AMYOTROPHIC LATERAL SCLEROSIS, NEURODEGENERATIVE DISORDERS
KG Connections6768 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.88
SASP-Mediated Complement Cascade Amplification
Score: 0.87
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.86
CYP46A1 Overexpression Gene Therapy
Score: 0.86
Transcriptional Autophagy-Lysosome Coupling
Score: 0.84

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

NEURODEGENERATION associated_with SIRT1
NEURODEGENERATION associated_with PERICYTE
NEURODEGENERATION associated_with NGF
NEURODEGENERATION associated_with T CELL
NEURODEGENERATION causes NEURON
NEURODEGENERATION causes NEURONS
NEURODEGENERATION protects_against NEURON
NEURODEGENERATION causes TREM2
NEURODEGENERATION regulates NEURON
NEURODEGENERATION contributes_to NEURON

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