| Gene Symbol | NPTX1 |
| Aliases | Neuronal Pentraxin 1 |
| Chromosome | 17q21.31. |
| Function | Neuronal Pentraxin 1 (NPTX1) is a member of the pentraxin family of proteins, which are characterized by their ability to bind to phosphatidylserine and apoptotic cells. |
| Molecular Weight | 47 kDa |
| Amino Acids | 430 aa |
| Pathways | oxidative stress response |
| Ensembl ID | ENSG00000143157 |
| GeneCards | NPTX1 |
| Human Protein Atlas | NPTX1 |
| CSF levels | Elevated NPTX1 levels in cerebrospinal fluid correlate with disease severity as measured by MMSE scores and CSF tau/phospho-tau levels (Chen et al., 2019; Song et al., 2021) |
| Synaptic loss | NPTX1 is released during synaptic degeneration, making it a marker of synaptic integrity (Yin et al., 2020) |
| Disease progression | Longitudinal studies show that NPTX1 can predict conversion from mild cognitive impairment (MCI) to AD with moderate accuracy (AUC ~0.75-0.80) |
| Pathology correlation | NPTX1 levels correlate with amyloid-beta plaque burden and neurofibrillary tangle density in postmortem brain tissue |
| CSF elevations | Multiple studies have demonstrated elevated CSF NPTX1 in PD patients compared to healthy controls (Ma et al., 2018) |
| Associated Diseases | Inflammation, Neuroinflammation |
| Interactions | AMYLOID, CHI3L1, CHIT1, CST3, CTSB, CTSD |
| KG Connections | 110 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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