gene 1,361 words KG: CHIT1 2026-03-28
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:microgliatopic:biomarker
Contents

CHIT1 Gene (Chitinase 1)

🧬 Gene Info
Gene SymbolCHIT1
Full NameChitinase 1
Chromosome1q32.1
Protein TypeEnzyme
Functionencodes a hydrolytic enzyme that degrades chitin, a polymer of N-acetylglucosamine found in fungal cell walls, insect exoskeletons, and some parasites.
Molecular Weight50 kDa
Amino Acids466 aa
Exons12
Pathwaysoxidative stress response
UniProt IDQ01228
NCBI Gene ID1118
Ensembl IDENSG00000133093
OMIM607203
GeneCardsCHIT1
Human Protein AtlasCHIT1
Associated DiseasesInflammation, Neuroinflammation
InteractionsAXL, CXCL10, MMP12, CXCL1, NPTX1, CHI3L1
KG Connections128 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: biomarker_for
Alzheimer Indonesia
institution · KG edge: biomarker_for
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: biomarker_for
CHI3L1 Gene
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

CHIT1 inhibits AXL
CHIT1 therapeutic_target MMP12
CHIT1 biomarker_for MDH1
CHIT1 associated_with PDGFRB
CHIT1 biomarker_for SQSTM1
CHIT1 biomarker_for BDNF
CHIT1 biomarker_for APOE
CHIT1 biomarker_for NEFL
CHIT1 associated_with CHI3L1
CHIT1 therapeutic_target CXCL1