gene 801 words KG: IL4 2026-03-24
kind:genesection:genesstate:published
Contents

IL4 Gene

🧬 Gene Info
Gene SymbolIL4
Full NameInterleukin 4
Chromosome5q31.3
FunctionThe IL4 gene encodes a protein involved in cellular signaling that is critical for development, tissue homeostasis, and immune regulation.
Primary Expressionvarious brain regions including cortex, hippocampus, and basal ganglia
Molecular Weight15 kDa
Amino Acids129 aa
PathwaysAutophagy
UniProt ID[P05112](https://www.uniprot.org/uniprot/P05112)
Ensembl IDENSG00000100994
GeneCardsIL4
Human Protein AtlasIL4
Associated DiseasesIschemia
InteractionsFGF2, IL9, IL6, TNF, LAMP2, STAT3
KG Connections208 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: biomarker_for
CHIT1 Gene (Chitinase 1)
gene · KG edge: biomarker_for
CHI3L1 Gene
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

IL4 upregulates IL9
IL4 promotes Anti-Inflammatory Reactivity
IL4 regulates ARRB1
IL4 regulates ARRB2
IL4 activates Microglia
IL4 activates FGF2
IL4 biomarker_for GFAP
IL4 biomarker_for NPTX1
IL4 biomarker_for CHIT1
IL4 biomarker_for MDH1