gene

CST3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CST3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections
0Hypotheses
0Analyses
26Outgoing
16Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolCST3
Full NameCystatin C
Chromosome20p11.21
FunctionCysteine protease inhibition
Molecular Weight13 kDa
Amino Acids120 aa
UniProt IDP01034
NCBI Gene ID1471
Ensembl IDENSG00000141540
OMIM123400
GeneCardsCST3
Human Protein AtlasCST3
Protein Size120 amino acids (~13 kDa)
BiomarkerStrengths
Aβ42Direct disease relevance
Associated DiseasesALS, Diabetes, Hypertension
InteractionsCTSS, NPTX1, SERPINA3, NRXN2, VGF, CTSB
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CST3 — AlphaFold P01034 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CST3 Gene - Cystatin C

gene · 2018 words

Microglial Cells — Cell Type Hierarchy

cell · 5150 words

TREM2 Mechanism Hub

mechanism · 5099 words

Neuroinflammation Microglia

cell_type · 3294 words

Microglia Activation Mechanism

mechanism · 3164 words

CTS Gene - Cathepsin S

gene · 3037 words

Pathway Diagram

graph TD
    CST3["<b>CST3</b>"]
    Alzheimer["Alzheimer"]
    CST3 -->|"regulates"| Alzheimer
    Als["Als"]
    CST3 -->|"activates"| Als
    Diabetes["Diabetes"]
    CST3 -->|"activates"| Diabetes
    Hypertension["Hypertension"]
    CST3 -->|"causes"| Hypertension
    ALS["ALS"]
    CST3 -->|"causes"| ALS
    Diabetes["Diabetes"]
    CST3 -->|"causes"| Diabetes
    APBB1["APBB1"]
    CST3 -->|"regulates"| APBB1
    FN1["FN1"]
    CST3 -->|"regulates"| FN1
    C1QA["C1QA"]
    CST3 -->|"regulates"| C1QA
    CTSS["CTSS"]
    CST3 -->|"activates"| CTSS
    NPTX1["NPTX1"]
    CST3 -->|"inhibits"| NPTX1
    SERPINA3["SERPINA3"]
    CST3 -->|"inhibits"| SERPINA3
    NRXN2["NRXN2"]
    CST3 -->|"inhibits"| NRXN2
    VGF["VGF"]
    CST3 -->|"inhibits"| VGF
    SYNAPSE["SYNAPSE"]
    CST3 -->|"inhibits"| SYNAPSE
    CTSB["CTSB"]
    CST3 -->|"activates"| CTSB
    CTSD["CTSD"]
    CST3 -->|"activates"| CTSD
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    CST3 -->|"causes"| DIABETES_MELLITUS
    Amyloid["Amyloid"]
    CST3 -->|"causes"| Amyloid
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| CST3
    APP["APP"]
    APP -->|"regulates"| CST3
    CLU["CLU"]
    CLU -->|"regulates"| CST3
    AMYLOID["AMYLOID"]
    AMYLOID -->|"inhibits"| CST3
    GENES["GENES"]
    GENES -->|"regulates"| CST3
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_DISEASE -->|"causes"| CST3
    C1QA["C1QA"]
    C1QA -->|"regulates"| CST3
    APBB1["APBB1"]
    APBB1 -->|"regulates"| CST3
    AND["AND"]
    AND -->|"causes"| CST3
    FN1["FN1"]
    FN1 -->|"regulates"| CST3
    AMYLOID["AMYLOID"]
    AMYLOID -->|"causes"| CST3

Outgoing (26)

TargetRelationTypeStr
Alzheimerregulatesdisease0.65
Alsactivatesdisease0.65
Diabetesactivatesdisease0.65
Hypertensioncausesdisease0.65
ALScausesdisease0.65

Incoming (16)

SourceRelationTypeStr
APPregulatesgene0.60
CLUregulatesgene0.60
C1QAregulatesgene0.60
APBB1regulatesgene0.60
APPco_discussedgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found