Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CST3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CST3 |
| Full Name | Cystatin C |
| Chromosome | 20p11.21 |
| Function | Cysteine protease inhibition |
| Molecular Weight | 13 kDa |
| Amino Acids | 120 aa |
| UniProt ID | P01034 |
| NCBI Gene ID | 1471 |
| Ensembl ID | ENSG00000141540 |
| OMIM | 123400 |
| GeneCards | CST3 |
| Human Protein Atlas | CST3 |
| Protein Size | 120 amino acids (~13 kDa) |
| Biomarker | Strengths |
| Aβ42 | Direct disease relevance |
| Associated Diseases | ALS, Diabetes, Hypertension |
| Interactions | CTSS, NPTX1, SERPINA3, NRXN2, VGF, CTSB |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CST3["<b>CST3</b>"]
Alzheimer["Alzheimer"]
CST3 -->|"regulates"| Alzheimer
Als["Als"]
CST3 -->|"activates"| Als
Diabetes["Diabetes"]
CST3 -->|"activates"| Diabetes
Hypertension["Hypertension"]
CST3 -->|"causes"| Hypertension
ALS["ALS"]
CST3 -->|"causes"| ALS
Diabetes["Diabetes"]
CST3 -->|"causes"| Diabetes
APBB1["APBB1"]
CST3 -->|"regulates"| APBB1
FN1["FN1"]
CST3 -->|"regulates"| FN1
C1QA["C1QA"]
CST3 -->|"regulates"| C1QA
CTSS["CTSS"]
CST3 -->|"activates"| CTSS
NPTX1["NPTX1"]
CST3 -->|"inhibits"| NPTX1
SERPINA3["SERPINA3"]
CST3 -->|"inhibits"| SERPINA3
NRXN2["NRXN2"]
CST3 -->|"inhibits"| NRXN2
VGF["VGF"]
CST3 -->|"inhibits"| VGF
SYNAPSE["SYNAPSE"]
CST3 -->|"inhibits"| SYNAPSE
CTSB["CTSB"]
CST3 -->|"activates"| CTSB
CTSD["CTSD"]
CST3 -->|"activates"| CTSD
DIABETES_MELLITUS["DIABETES MELLITUS"]
CST3 -->|"causes"| DIABETES_MELLITUS
Amyloid["Amyloid"]
CST3 -->|"causes"| Amyloid
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"regulates"| CST3
APP["APP"]
APP -->|"regulates"| CST3
CLU["CLU"]
CLU -->|"regulates"| CST3
AMYLOID["AMYLOID"]
AMYLOID -->|"inhibits"| CST3
GENES["GENES"]
GENES -->|"regulates"| CST3
ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
ALZHEIMER_DISEASE -->|"causes"| CST3
C1QA["C1QA"]
C1QA -->|"regulates"| CST3
APBB1["APBB1"]
APBB1 -->|"regulates"| CST3
AND["AND"]
AND -->|"causes"| CST3
FN1["FN1"]
FN1 -->|"regulates"| CST3
AMYLOID["AMYLOID"]
AMYLOID -->|"causes"| CST3| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | regulates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| Hypertension | causes | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Diabetes | causes | disease | 0.65 |
| Hypertension | activates | disease | 0.65 |
| APBB1 | regulates | gene | 0.60 |
| C1QA | regulates | gene | 0.60 |
| CTSS | activates | gene | 0.60 |
| NPTX1 | inhibits | gene | 0.60 |
| SERPINA3 | inhibits | gene | 0.60 |
| NRXN2 | inhibits | gene | 0.60 |
| VGF | inhibits | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| CLU | regulates | gene | 0.60 |
| SCA3 | associated_with | gene | 0.60 |
| FN1 | regulates | gene | 0.60 |
| SYNAPSE | inhibits | gene | 0.60 |
| DIABETES MELLITUS | causes | gene | 0.60 |
| Amyloid | causes | pathway | 0.60 |
| Amyloid | activates | protein | 0.60 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| ALZHEIMER | regulates | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APP | regulates | gene | 0.60 |
| CLU | regulates | gene | 0.60 |
| C1QA | regulates | gene | 0.60 |
| APBB1 | regulates | gene | 0.60 |
| APP | co_discussed | gene | 0.60 |
| CLU | co_discussed | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| ALZHEIMER DISEASE | causes | gene | 0.60 |
| AND | causes | gene | 0.60 |
| FN1 | regulates | gene | 0.60 |
| AMYLOID | causes | gene | 0.60 |
| ALZHEIMER | co_discussed | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| apbb1 | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||