gene

CHIT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHIT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

Summary

CHIT1 encodes chitotriosidase, a chitinase enzyme expressed in activated microglia and implicated as a biomarker in Alzheimer's disease, Parkinson's disease, and Gaucher disease

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🧬 Gene Info

Gene Symbol	CHIT1
Full Name	Chitinase 1
Chromosome	1q32.1
Protein Type	Enzyme
Function	encodes a hydrolytic enzyme that degrades chitin, a polymer of N-acetylglucosamine found in fungal cell walls, insect exoskeletons, and some parasites.
Molecular Weight	50 kDa
Amino Acids	466 aa
Exons	12
Pathways	oxidative stress response
UniProt ID	Q01228
NCBI Gene ID	1118
Ensembl ID	ENSG00000133093
OMIM	607203
GeneCards	CHIT1
Human Protein Atlas	CHIT1
Associated Diseases	Inflammation, Neuroinflammation
Interactions	AXL, CXCL10, MMP12, CXCL1, NPTX1, CHI3L1
KG Connections	128 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHIT1 — AlphaFold Q01228 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHIT1["CHIT1"] -->|"therapeutic target"| Atherosclerosis["Atherosclerosis"]
    CHIT1["CHIT1"] -.->|"inhibits"| Als["Als"]
    CHIT1["CHIT1"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    CHIT1["CHIT1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    CHIT1["CHIT1"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    CHIT1["CHIT1"] -->|"biomarker for"| Als_1["Als"]
    CXCL1["CXCL1"] -->|"therapeutic target"| CHIT1["CHIT1"]
    CXCL10["CXCL10"] -->|"therapeutic target"| CHIT1["CHIT1"]
    IL9["IL9"] -->|"biomarker for"| CHIT1["CHIT1"]
    VEGFA["VEGFA"] -->|"associated"| CHIT1["CHIT1"]
    style CHIT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (85)

Target	Relation	Type	Str
Tau Pathology	biomarker_for	process	0.85
oxidative stress response	participates_in	pathway	0.70
Atherosclerosis	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
ALS	biomarker_for	disease	0.65
AXL	inhibits	gene	0.60
MMP12	therapeutic_target	gene	0.60
MDH1	biomarker_for	gene	0.60
PDGFRB	associated_with	gene	0.60
SQSTM1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
APOE	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
CHI3L1	associated_with	gene	0.60
CXCL1	therapeutic_target	gene	0.60
FGF2	biomarker_for	gene	0.60
IL9	biomarker_for	gene	0.60
IL4	biomarker_for	gene	0.60
NPTX1	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
GFAP	biomarker_for	gene	0.60
CXCL10	therapeutic_target	gene	0.60
CXCL10	inhibits	gene	0.60
MMP12	inhibits	gene	0.60
NPTX1	biomarker_for	entity	0.60
PDGFRB	biomarker_for	entity	0.60
TAU	biomarker_for	entity	0.60
VEGFA	biomarker_for	entity	0.60
CXCL1	inhibits	gene	0.60
TAU	associated_with	gene	0.60
Vegf	associated_with	protein	0.60
Rb	associated_with	protein	0.60
PDGFRB	interacts_with	gene	0.60
neuroinflammation	interacts_with	disease	0.60
NPTX1	activates	gene	0.60
PDGFRB	activates	gene	0.60
neuroinflammation	activates	disease	0.60
Innate Immunity	therapeutic_target	pathway	0.60
Amyloid	biomarker_for	pathway	0.60

Incoming (43)

Source	Relation	Type	Str
CXCL1	therapeutic_target	gene	0.60
CXCL10	therapeutic_target	gene	0.60
IL9	biomarker_for	gene	0.60
VEGFA	associated_with	gene	0.60
IL4	biomarker_for	gene	0.60
FGF2	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
NPTX1	associated_with	gene	0.60
MMP12	therapeutic_target	gene	0.60
SQSTM1	biomarker_for	gene	0.60
AXL	inhibits	gene	0.60
APOE	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
CXCL1	inhibits	gene	0.60
CHI3L1	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
TAU	associated_with	gene	0.60
MDH1	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
MMP12	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
AXL	downregulates	entity	0.60
CHI3L1	biomarker_for	entity	0.60
AXL	associated_with	gene	0.60
CHI3L1	interacts_with	gene	0.60
CHI3L1	activates	gene	0.60
CXCL9	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
INFLAMMATION	associated_with	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
IL-6	inhibits	gene	0.60
AND	inhibits	gene	0.60
AND	associated_with	gene	0.60
PDGFRB	interacts_with	gene	0.50
Neuroinflammation	interacts_with	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHIT1

Understanding Entity Pages

Summary

Wiki Pages (19)

CHIT1 Gene (Chitinase 1)

Cerebrospinal Fluid (CSF) Biomarkers Overview

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Liquid Biopsy Diagnostics for Corticobasal Syndrome

FTD-ALS Spectrum

NPTX1 Protein

Gaucher Disease

Meso Scale Discovery (MSD) Electrochemiluminescence Platform

Multi-Analyte Biomarker Panels for Neurodegeneration

Cerebrospinal Fluid (CSF) Biomarker Panels

Chitotriosidase - Biomarker

Cerebrospinal Fluid in Neurodegenerative Disease

Olink Proteomics

A/T/N+ Comprehensive Biomarker Panel for Alzheimer's Disease Staging

Biomarkers Dashboard

Microglial Activation Biomarker Panel for Neurodegenerative Diseases

Oligodendrocytes in Neurodegeneration