cell 536 words KG: Ca1 2026-03-24
kind:cell-typesection:cell-typesstate:published
Contents

Vulnerable Hippocampal CA1 Pyramidal Neurons in Alzheimer's Disease

🧫 Cell Type Info
Cell TypeVulnerable Hippocampal CA1 Pyramidal Neurons in Alzheimer's Disease
Also Known AsCA-I, Carbonate dehydratase I
Key PathwayspH regulation, CO2 transport
Associated DiseasesMetabolic acidosis
Related GenesABCA1, MTOR, P62, LC3, APOE, SQSTM1
Linked Hypotheses122 hypotheses

Knowledge Graph

Related Hypotheses (24)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (24)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

Related Experiments (30)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (15)

Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 18 hypotheses
Ubiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypotheses
Tau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Tau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses

Knowledge Graph (12 edges)

ABCA1 expressed_in Ca1
MTOR expressed_in Ca1
P62 expressed_in Ca1
LC3 expressed_in Ca1
APOE expressed_in Ca1
SQSTM1 expressed_in Ca1
LDL expressed_in Ca1
AMPK expressed_in Ca1
ACTB expressed_in Ca1
ALS expressed_in Ca1