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cell 536 words KG: Ca1
Contents

Vulnerable Hippocampal CA1 Pyramidal Neurons in Alzheimer's Disease

🧫 Cell Type Info
Cell TypeCa1
Also Known AsCA-I, Carbonate dehydratase I
Key PathwayspH regulation, CO2 transport
Associated DiseasesMetabolic acidosis
Related GenesABCA1, ABCG1, ACTB, AKT, ALS, ALZHEIMER
Linked Hypotheses442 hypotheses

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Wikipedia

Related Hypotheses (24)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60VCP-Mediated Autophagy Enhancement
Score: 0.59Extracellular Vesicle Biogenesis Modulation
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Senescent Cell Mitochondrial DNA Release
Score: 0.74Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
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Related Analyses (21)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Protein Aggregation Kinetic Validation Results
validation · proposed · Score: 0.40Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40

See Also (15)

ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDigital Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDried Blood Spot Biomarker Test for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDTI Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesEEG Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses

Knowledge Graph (12 edges)

ABCA1 expressed_in Ca1
MTOR expressed_in Ca1
P62 expressed_in Ca1
LC3 expressed_in Ca1
APOE expressed_in Ca1
SQSTM1 expressed_in Ca1
LDL expressed_in Ca1
AMPK expressed_in Ca1
ACTB expressed_in Ca1
ALS expressed_in Ca1

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