gene 1,733 words KG: TRAF2 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammation
Contents

TRAF2 Gene

🧬 Gene Info
Gene SymbolTRAF2
Full NameTNF Receptor Associated Factor 2
AliasesTRAP, TNF-R2-associated factor, MORT1-associated protein
Chromosome9q34.3
Protein TypeLigase
Functionencodes a critical E3 ubiquitin ligase that serves as a central adaptor protein in TNF receptor signaling pathways.
Molecular Weight56 kDa
Amino Acids522 aa
PathwaysNF-κB signaling, NF-κB, MAPK
UniProt IDQ9UAV6
NCBI Gene ID7186
Ensembl IDENSG00000126933
OMIM601985
GeneCardsTRAF2
Human Protein AtlasTRAF2
Associated DiseasesTumor
InteractionsTNF, STING, CGAS, TRAF6, IRF1, TGFBR1
KG Connections160 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Autophagosome Maturation Checkpoint Control
Score: 0.49
Cryptic Exon Silencing Restoration
Score: 0.46
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Cross-Seeding Prevention Strategy
Score: 0.45

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates
FIS1 Gene
gene · KG edge: associated_with
DISC1 — Disrupted in Schizophrenia 1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TRAF2 activates TNF
TRAF2 associated_with DNM1L
TRAF2 associated_with NLRP3
TRAF2 activates STING
TRAF2 activates CGAS
TRAF2 regulates SMAD3
TRAF2 regulates CREBBP
TRAF2 associated_with RIPK1
TRAF2 interacts_with TRAF6
TRAF2 interacts_with IRF1