gene 1,383 words KG: ent-gene-caf074c2 2026-03-29
kind:genesection:entitiesstate:publishedevidence:strong
Contents

HTT — Huntingtin Gene Entity Page

🧬 Gene Info
Gene SymbolHTT
Full NameHuntingtin
Chromosome4p16.3
Functionis a large, multifunctional protein encoded by the HTT gene on chromosome 4p16.
Primary ExpressionStriatum (caudate/putamen), Cortex, Hippocampus, Cerebellum
Molecular Weight350 kDa
Amino Acids144 aa
Exons67
PathwaysAutophagy, Dna Repair
UniProt IDP42857
NCBI Gene ID3064
Ensembl IDENSG00000197393
OMIM143100
GeneCardsHTT
Human Protein AtlasHTT
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, dimethyl fumarate, rapamycin
InteractionsP62, SQSTM1, TFEB, ULK1, MTOR, NFL
KG Connections699 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph