SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
mechanism 1,042 words KG: MAPT
Contents

ftdp-17-genetics-mapt-mutations

⚙ Mechanism Info
NameMAPT
Key Genes/Proteins0N3R, A2M, ABCA1, ABCA2, ABCA7, ACE
Related Diseases4R Tauopathy, AD
Linked Hypotheses8 hypotheses

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

Wikipedia

Related Hypotheses (58)

Microglial-Mediated Tau Clearance Dysfunction via TREM2 Rece
Score: 0.94Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.86MAPT tau seeding and release across AD, FTD, and PD-spectrum
Score: 0.81Dual-Circuit Tau Vulnerability Cascade
Score: 0.77Cholinergic Basal Forebrain-Hippocampal Circuit Protection
Score: 0.76Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanis
Score: 0.76Repeat-domain exposure defines seed-competent tau conformers
Score: 0.76Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio
Score: 0.75Tau dysfunction destabilizes labile pool
Score: 0.75Tau/MAP6 ratio as a master switch for microtubule dynamics p
Score: 0.75Tau missorting transitions into an autonomous tau-seeding st
Score: 0.74A tau PTM barcode gates trans-synaptic templating
Score: 0.74Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in
Score: 0.73Microglial TREM2-Mediated Tau Phagocytosis Impairment
Score: 0.68Selective Tau Kinase Inhibition in Vulnerable Neuronal Subty
Score: 0.68Fyn-anchored dendritic tau/NMDAR signaling persists after tr
Score: 0.67Locus Coeruleus-Hippocampal Circuit Protection
Score: 0.67Glymphatic-Cholinergic Tau Clearance Cascade
Score: 0.67Excitatory Neuron Synaptic Dysfunction and Mitochondrial Str
Score: 0.66Competition-based domain allocation
Score: 0.65
pg 1/3Next →

Knowledge Graph (12 edges)

MAPT encodes TAU
NCSTN interacts_with MAPT
FAS interacts_with MAPT
TNF interacts_with MAPT
LMNA interacts_with MAPT
APH1B interacts_with MAPT
APOE activates MAPT
IL6 interacts_with MAPT
SREBF1 activates MAPT
PSEN2 activates MAPT

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas